Literature DB >> 21195344

The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology.

Bryan Krock1, Nicolas Skuli, M Celeste Simon.   

Abstract

How cellular metabolism regulates stem cell function is poorly understood but is an emerging field of study. In a recent issue of Nature, three independent groups demonstrate that LKB1 promotes hematopoietic stem cell (HSC) quiescence and metabolic homeostasis. Surprisingly, these effects on HSCs occur independently of AMPK/mTOR and FoxO signaling. Copyright Â
© 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21195344     DOI： 10.1016/j.cmet.2010.12.015

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  13 in total

1.  Liver Kinase B1 Fine-Tunes Lineage Commitment of Human Fetal Synovium-Derived Stem Cells.

Authors:  Sheng Zhou; Yawen Fu; Xiao-Bing Zhang; Ming Pei
Journal:  J Orthop Res       Date:  2019-08-30       Impact factor: 3.494

2.  LKB1 regulates germinal center formation and termination.

Authors:  Lynnea R Waters; Nicole C Walsh; Michael A Teitell
Journal:  Cell Cycle       Date:  2015-06-01       Impact factor: 4.534

3.  Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis.

Authors:  Tizhong Shan; Pengpeng Zhang; Xinrong Liang; Pengpeng Bi; Feng Yue; Shihuan Kuang
Journal:  Stem Cells       Date:  2014-11       Impact factor: 6.277

Review 4.  Targeting the LKB1 tumor suppressor.

Authors:  Rui-Xun Zhao; Zhi-Xiang Xu
Journal:  Curr Drug Targets       Date:  2014-01       Impact factor: 3.465

5.  Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition.

Authors:  Cuiqing Fan; Chuntao Zhao; Feng Zhang; Meenu Kesarwani; Zhaowei Tu; Xiongwei Cai; Ashley Kuenzi Davis; Lingli Xu; Cindy L Hochstetler; Xiaoyi Chen; Fukun Guo; Gang Huang; Mohammad Azam; Weidong Tian; Q Richard Lu; Yi Zheng
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-21       Impact factor: 11.205

6.  MicroRNA-17 promotes normal ovarian cancer cells to cancer stem cells development via suppression of the LKB1-p53-p21/WAF1 pathway.

Authors:  Te Liu; Wenxing Qin; Lengchen Hou; Yongyi Huang
Journal:  Tumour Biol       Date:  2014-12-16

7.  A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.

Authors:  Zhi-Feng Miao; Mahliyah Adkins-Threats; Joseph R Burclaff; Luciana H Osaki; Jing-Xu Sun; Yan Kefalov; Zheng He; Zhen-Ning Wang; Jason C Mills
Journal:  Cell Stem Cell       Date:  2020-04-02       Impact factor: 24.633

8.  Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts.

Authors:  Tizhong Shan; Pengpeng Zhang; Yan Xiong; Yizhen Wang; Shihuan Kuang
Journal:  Int J Biochem Cell Biol       Date:  2016-04-27       Impact factor: 5.085

9.  Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways.

Authors:  Jian Huang; Michelle Nguyen-McCarty; Elizabeth O Hexner; Gwenn Danet-Desnoyers; Peter S Klein
Journal:  Nat Med       Date:  2012-11-11       Impact factor: 53.440

10.  Isoflurane suppresses the self-renewal of normal mouse neural stem cells in a p53-dependent manner by activating the Lkb1-p53-p21 signalling pathway.

Authors:  Lengchen Hou; Te Liu; Jian Wang
Journal:  Mol Med Rep       Date:  2015-09-29       Impact factor: 2.952
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.