The etiology of Paget's disease of bone: viral and genetic interactions.

Studies of the etiology of Paget's disease have focused separately on the viral and genetic components of the disease. In this issue of Cell Metabolism, Kurihara et al. (2011) join these components, reporting that sequestosome 1 mutation in patients and mice activates osteoclasts, while measles virus induces the phenotype of Paget's disease. Copyright Â