| Literature DB >> 21194809 |
Ahmed Kamal1, E Vijaya Bharathi, J Surendranadha Reddy, M Janaki Ramaiah, D Dastagiri, M Kashi Reddy, A Viswanath, T Lakshminarayan Reddy, T Basha Shaik, S N C V L Pushpavalli, Manika Pal Bhadra.
Abstract
A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer activity. One of the compounds 4c amongst this series has shown promising anticancer activity. Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this conjugate. Copyright ÂEntities:
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Year: 2010 PMID： 21194809 DOI： 10.1016/j.ejmech.2010.12.004
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514