Literature DB >> 21194365

The multidrug transporter Pdr5: a molecular diode?

Rakeshkumar P Gupta1, Petra Kueppers, Lutz Schmitt, Robert Ernst.   

Abstract

A subset of the family of ATP-binding cassette (ABC) transporters has been in focus owing to their involvement in conferring multidrug resistance in cancer cells and among immune compromised individuals. Saccharomyces cerevisiae is protected against xenobiotics by similar machineries that are part of the pleitropic drug resistance (PDR) network. The ABC transporter Pdr5 is an important member of this PDR network in yeast and is involved in cellular detoxification by the efflux of a wide variety of drugs and substrates. In this review, we focus on the aspects of detergent effects and the degeneracy in conserved sequences that is observed in the nucleotide binding domains of Pdr5 and discuss their functional relevance.

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Year:  2011        PMID： 21194365     DOI： 10.1515/BC.2011.011

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  10 in total

1.  The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycle.

Authors:  Christopher Furman; Jitender Mehla; Neeti Ananthaswamy; Nidhi Arya; Bridget Kulesh; Ildiko Kovach; Suresh V Ambudkar; John Golin
Journal:  J Biol Chem       Date:  2013-09-09       Impact factor: 5.157

2.  Evidence for a molecular diode-based mechanism in a multispecific ATP-binding cassette (ABC) exporter: SER-1368 as a gatekeeping residue in the yeast multidrug transporter Pdr5.

Authors:  Jitender Mehla; Robert Ernst; Rachel Moore; Adina Wakschlag; Mary Kate Marquis; Suresh V Ambudkar; John Golin
Journal:  J Biol Chem       Date:  2014-08-11       Impact factor: 5.157

3.  Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.

Authors:  Manpreet Kaur Rawal; Mohammad Firoz Khan; Khyati Kapoor; Neha Goyal; Sobhan Sen; Ajay Kumar Saxena; Andrew M Lynn; Joel D A Tyndall; Brian C Monk; Richard D Cannon; Sneha Sudha Komath; Rajendra Prasad
Journal:  J Biol Chem       Date:  2013-07-03       Impact factor: 5.157

4.  Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor.

Authors:  Kyoko Niimi; David R K Harding; Ann R Holmes; Erwin Lamping; Masakazu Niimi; Joel D A Tyndall; Richard D Cannon; Brian C Monk
Journal:  Mol Microbiol       Date:  2012-07-13       Impact factor: 3.501

Review 5.  The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters.

Authors:  John Golin; Suresh V Ambudkar
Journal:  Biochem J       Date:  2015-05-01       Impact factor: 3.857

6.  Mutations of charged amino acids at the cytoplasmic end of transmembrane helix 2 affect transport activity of the budding yeast multidrug resistance protein Pdr5p.

Authors:  Weiwang Dou; Jianhua Zhu; Tanjun Wang; Wei Wang; Han Li; Xin Chen; Wenjun Guan
Journal:  FEMS Yeast Res       Date:  2016-04-19       Impact factor: 2.796

7.  FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops.

Authors:  Koichi Tanabe; Michele Bonus; Susumu Tomiyama; Kunji Miyoshi; Minoru Nagi; Kyoko Niimi; Ariya Chindamporn; Holger Gohlke; Lutz Schmitt; Richard D Cannon; Masakazu Niimi; Erwin Lamping
Journal:  Antimicrob Agents Chemother       Date:  2018-12-21       Impact factor: 5.191

8.  Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition.

Authors:  Masakazu Niimi; Kyoko Niimi; Koichi Tanabe; Richard D Cannon; Erwin Lamping
Journal:  Antimicrob Agents Chemother       Date:  2021-11-15       Impact factor: 5.191

Review 9.  Efflux pump proteins in antifungal resistance.

Authors:  Rajendra Prasad; Manpreet K Rawal
Journal:  Front Pharmacol       Date:  2014-08-29       Impact factor: 5.810

10.  Lipophilic Cations Rescue the Growth of Yeast under the Conditions of Glycolysis Overflow.

Authors:  Svyatoslav S Sokolov; Ekaterina A Smirnova; Olga V Markova; Natalya A Kireeva; Roman S Kirsanov; Liudmila S Khailova; Dmitry A Knorre; Fedor F Severin
Journal:  Biomolecules       Date:  2020-09-20
  10 in total

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