BACKGROUND/ OBJECTIVE: This study used a case-control female sample to test psychiatric mediators and genetic moderators of the effect of sexual abuse on later alcohol dependence. The study also tested differences between alcohol dependent women with or without a history of sexual abuse on variables that might affect treatment planning. METHODS: A case-control design compared 192 treatment-seeking alcohol dependent women with 177 healthy population controls. All participants were assessed for alcohol-related behaviors, sexual abuse history, psychiatric problems, and personality functioning. Markers were genotyped in the CRHR1, MAO-A and OPRM1 genes. RESULTS: The association of sexual abuse with alcohol dependence was limited to the most severe category of sexual abuse involving anal or vaginal penetration. Of the five psychiatric disorders tested, anxiety, anorexia nervosa, and bulimia met criteria as potential mediators of the abuse-alcohol dependence association. Severe sexual abuse continued to have an independent effect on alcohol dependence status even after accounting for these potential mediators. None of the candidate genetic markers moderated the association between sexual abuse and alcohol dependence. Of alcohol dependent participants, those with a history of severe abuse rated higher on alcoholism severity, and psychiatric comorbidities. CONCLUSION: Sexual abuse is associated with later alcohol problems directly as well as through its effect on psychiatric problems. Treatment-seeking alcohol dependent women with a history of abuse have distinct features as compared to other alcohol dependent women.
BACKGROUND/ OBJECTIVE: This study used a case-control female sample to test psychiatric mediators and genetic moderators of the effect of sexual abuse on later alcohol dependence. The study also tested differences between alcohol dependent women with or without a history of sexual abuse on variables that might affect treatment planning. METHODS: A case-control design compared 192 treatment-seeking alcohol dependent women with 177 healthy population controls. All participants were assessed for alcohol-related behaviors, sexual abuse history, psychiatric problems, and personality functioning. Markers were genotyped in the CRHR1, MAO-A and OPRM1 genes. RESULTS: The association of sexual abuse with alcohol dependence was limited to the most severe category of sexual abuse involving anal or vaginal penetration. Of the five psychiatric disorders tested, anxiety, anorexia nervosa, and bulimia met criteria as potential mediators of the abuse-alcohol dependence association. Severe sexual abuse continued to have an independent effect on alcohol dependence status even after accounting for these potential mediators. None of the candidate genetic markers moderated the association between sexual abuse and alcohol dependence. Of alcohol dependent participants, those with a history of severe abuse rated higher on alcoholism severity, and psychiatric comorbidities. CONCLUSION:Sexual abuse is associated with later alcohol problems directly as well as through its effect on psychiatric problems. Treatment-seeking alcohol dependent women with a history of abuse have distinct features as compared to other alcohol dependent women.
Authors: S Dinwiddie; A C Heath; M P Dunne; K K Bucholz; P A Madden; W S Slutske; L J Bierut; D B Statham; N G Martin Journal: Psychol Med Date: 2000-01 Impact factor: 7.723
Authors: Elliot C Nelson; Arpana Agrawal; Michele L Pergadia; Jen C Wang; John B Whitfield; F Scott Saccone; Jason Kern; Julia D Grant; Andrew J Schrage; John P Rice; Grant W Montgomery; Andrew C Heath; Alison M Goate; Nicholas G Martin; Pamela A F Madden Journal: Addict Biol Date: 2010-01 Impact factor: 4.280
Authors: Sebastian Trautmann; Jan Richter; Markus Muehlhan; Michael Höfler; Hans-Ulrich Wittchen; Katharina Domschke; Andreas Ströhle; Alfons O Hamm; Heike Weber; Tilo Kircher; Volker Arolt; Alexander L Gerlach; Georg W Alpers; Thomas Fydrich; Thomas Lang; Andreas Reif Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-07-15 Impact factor: 5.270
Authors: Melanie L Schwandt; Markus Heilig; Daniel W Hommer; David T George; Vijay A Ramchandani Journal: Alcohol Clin Exp Res Date: 2012-12-27 Impact factor: 3.455