PURPOSE OF REVIEW: Balamuthia mandrillaris infection of the skin and central nervous system has been increasingly reported in the last decade, making this entity a genuine emerging disease. The ability of the clinician in recognizing the skin lesion early in the course of the disease may lead to a successful therapeutic intervention in an otherwise fatal disease. RECENT FINDINGS: In the past years, advances have been made regarding knowledge about the ubiquity of the ameba in the environment, its worldwide distribution (with higher prevalence in South America), the patients at risk (particularly those of Hispanic origin), the diagnostic methods (including those based on molecular biology) and the different therapeutic strategies that have resulted in survival of patients. A recent report dealing with organ transplant transmission of this infection has made it a subject of interest in transplant medicine. SUMMARY: The present review will allow readers from different fields (clinician, dermatologist, neurologist, infectious disease and transplant specialist) to become familiar with the clinical aspect of the disease, including diagnosis and therapy.
PURPOSE OF REVIEW: Balamuthia mandrillaris infection of the skin and central nervous system has been increasingly reported in the last decade, making this entity a genuine emerging disease. The ability of the clinician in recognizing the skin lesion early in the course of the disease may lead to a successful therapeutic intervention in an otherwise fatal disease. RECENT FINDINGS: In the past years, advances have been made regarding knowledge about the ubiquity of the ameba in the environment, its worldwide distribution (with higher prevalence in South America), the patients at risk (particularly those of Hispanic origin), the diagnostic methods (including those based on molecular biology) and the different therapeutic strategies that have resulted in survival of patients. A recent report dealing with organ transplant transmission of this infection has made it a subject of interest in transplant medicine. SUMMARY: The present review will allow readers from different fields (clinician, dermatologist, neurologist, infectious disease and transplant specialist) to become familiar with the clinical aspect of the disease, including diagnosis and therapy.
Authors: Katherine R Schafer; Neil Shah; M I Almira-Suarez; Jennifer M Reese; George M Hoke; James W Mandell; Sharon L Roy; Govinda Visvesvara Journal: J Clin Microbiol Date: 2015-07-01 Impact factor: 5.948
Authors: A A Gupte; S N Hocevar; A S Lea; R D Kulkarni; D C Schain; M J Casey; I R Zendejas-Ruiz; W K Chung; C Mbaeyi; S L Roy; G S Visvesvara; A J da Silva; J Tallaj; D Eckhoff; J W Baddley Journal: Am J Transplant Date: 2014-05-19 Impact factor: 8.086
Authors: Kathleen E Sullivan; Hamid Bassiri; Ahmed A Bousfiha; Beatriz T Costa-Carvalho; Alexandra F Freeman; David Hagin; Yu L Lau; Michail S Lionakis; Ileana Moreira; Jorge A Pinto; M Isabel de Moraes-Pinto; Amit Rawat; Shereen M Reda; Saul Oswaldo Lugo Reyes; Mikko Seppänen; Mimi L K Tang Journal: J Clin Immunol Date: 2017-08-07 Impact factor: 8.317
Authors: Sharon L Roy; Jane T Atkins; Rosemaria Gennuso; Danny Kofos; Rama R Sriram; Thomas P C Dorlo; Teresa Hayes; Yvonne Qvarnstrom; Zuzana Kucerova; B Joseph Guglielmo; Govinda S Visvesvara Journal: Parasitol Res Date: 2015-09-02 Impact factor: 2.289
Authors: A Krasaelap; S Prechawit; J Chansaenroj; P Punyahotra; T Puthanakit; K Chomtho; S Shuangshoti; J Amornfa; Y Poovorawan Journal: Korean J Parasitol Date: 2013-06-30 Impact factor: 1.341
Authors: Matthew T Laurie; Corin V White; Hanna Retallack; Wesley Wu; Matthew S Moser; Judy A Sakanari; Kenny Ang; Christopher Wilson; Michelle R Arkin; Joseph L DeRisi Journal: mBio Date: 2018-10-30 Impact factor: 7.867