Literature DB >> 21191307

Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study.

Vibeke Andersen1, Jane Christensen, Kim Overvad, Anne Tjønneland, Ulla Vogel.   

Abstract

OBJECTIVE: Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.
METHODS: Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.
RESULTS: No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates = 0.29). No interaction with meat intake was found (P value for interaction = 0.55).
CONCLUSION: The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21191307     DOI： 10.1097/MEG.0b013e3283417f76

Source DB:  PubMed          Journal:  Eur J Gastroenterol Hepatol        ISSN： 0954-691X            Impact factor:   2.566


  12 in total

1.  Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study.

Authors:  Vibeke Andersen; Rikke Egeberg; Anne Tjønneland; Ulla Vogel
Journal:  BMC Cancer       Date:  2012-05-17       Impact factor: 4.430

2.  Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study.

Authors:  Vibeke Andersen; Anja Ernst; Jurgita Sventoraityte; Limas Kupcinskas; Bent A Jacobsen; Henrik B Krarup; Ulla Vogel; Laimas Jonaitis; Goda Denapiene; Gediminas Kiudelis; Tobias Balschun; Andre Franke
Journal:  BMC Med Genet       Date:  2011-10-13       Impact factor: 2.103

3.  No association between HMOX1 and risk of colorectal cancer and no interaction with diet and lifestyle factors in a prospective Danish case-cohort study.

Authors:  Vibeke Andersen; Tine Iskov Kopp; Anne Tjønneland; Ulla Vogel
Journal:  Int J Mol Sci       Date:  2015-01-07       Impact factor: 5.923

4.  Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study.

Authors:  Tine Iskov Kopp; Vibeke Andersen; Anne Tjonneland; Ulla Vogel
Journal:  PLoS One       Date:  2015-02-23       Impact factor: 3.240

5.  Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis.

Authors:  Rui Wang; Jun Shen; Rui Yang; Wan-Guo Wang; Ye Yuan; Zhong-Hua Guo
Journal:  Biomed Rep       Date:  2018-01-25

Review 6.  Systematic review: diet-gene interactions and the risk of colorectal cancer.

Authors:  V Andersen; R Holst; U Vogel
Journal:  Aliment Pharmacol Ther       Date:  2012-12-10       Impact factor: 8.171

7.  Interactions between diet, lifestyle and IL10, IL1B, and PTGS2/COX-2 gene polymorphisms in relation to risk of colorectal cancer in a prospective Danish case-cohort study.

Authors:  Vibeke Andersen; René Holst; Tine Iskov Kopp; Anne Tjønneland; Ulla Vogel
Journal:  PLoS One       Date:  2013-10-23       Impact factor: 3.240

8.  Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis.

Authors:  Lotte K Vogel; Mona Sæbø; Helle Høyer; Tine Iskov Kopp; Ulla Vogel; Sine Godiksen; Franz B Frenzel; Julian Hamfjord; Inger Marie Bowitz-Lothe; Egil Johnson; Elin H Kure; Vibeke Andersen
Journal:  PLoS One       Date:  2014-08-28       Impact factor: 3.240

Review 9.  Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer.

Authors:  V Andersen; U Vogel
Journal:  Aliment Pharmacol Ther       Date:  2014-05-28       Impact factor: 8.171

10.  Interactions between meat intake and genetic variation in relation to colorectal cancer.

Authors:  Vibeke Andersen; Ulla Vogel
Journal:  Genes Nutr       Date:  2014-12-10       Impact factor: 5.523
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.