| Literature DB >> 21190851 |
Christian Fischer1, Sanjiv Shah, Bethany L Hughes, George N Nikov, Jamie L Crispino, Richard E Middleton, Alexander A Szewczak, Benito Munoz, Mark S Shearman.
Abstract
Synthesis, SAR and evaluation of styrenyl quinazolinones as novel gamma secretase modulators are presented in this communication. Starting from literature and in-house leads we evaluated a range of quinazolinones which showed good modulation of γ-secretase activity. Copyright ÂEntities:
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Year: 2010 PMID： 21190851 DOI： 10.1016/j.bmcl.2010.11.111
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823