| Literature DB >> 21190848 |
Chul Min Park1, Jin Il Choi, Jung Hwan Choi, So Young Kim, Woo Kyu Park, Churl Min Seong.
Abstract
Piperazinyl derivatives of 1-(arylsulfonyl)-2,3-dihydro-1H-quinolin-4-ones have been identified with high binding affinities for 5-HT(6) receptor. In particular, 2-methyl-5-(N-methyl-piperazin-1-yl)-1-(naphthalene-2-sulfonyl)-2,3-dihydro-1H-quinolin-4-one (8g) exhibits high binding affinity toward 5-HT(6) (IC(50)=8nM) receptor with good selectivity over other serotonin and dopamine receptors. Copyright ÂEntities:
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Year: 2010 PMID： 21190848 DOI： 10.1016/j.bmcl.2010.12.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823