| Literature DB >> 21190821 |
Joao G Magalhaes1, Matthew T Sorbara, Stephen E Girardin, Dana J Philpott.
Abstract
Over the last few years, much research has focused on determining the function of members of the cytosolic Nod-like receptor (NLR) family in terms of their triggers and the signaling pathways that they control. Members of this family include the NLRP proteins, which play a role in sensing both microbial and danger signals and triggering the caspase-1 dependent inflammasome, and the Nod subfamily characterized by proteins with a caspase-activating and recruitment domain (CARD) or a so-called 'X' domain. Nod1, Nod2, NLRX1 and NLRC5 are all members of this subfamily and in this review, we will focus on recent work that has shown the importance of these molecules in both pathogen sensing and regulation of innate and adaptive immunity.Entities:
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Year: 2010 PMID： 21190821 DOI： 10.1016/j.coi.2010.12.003
Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486