Literature DB >> 21190525

Role of α6β4 integrin in cell motility, invasion and metastasis of mammary tumors.

Young Hwa Soung1, Hyea Jin Gil, John L Clifford, Jun Chung.   

Abstract

Integrin α6β4 is the receptor for the laminin family of extracellular matrix proteins and is widely expressed in most epithelial tissues and Schwann cells. The expression of this integrin is up-regulated in most epithelial tumors, suggesting the role of α6β4 in their progression. The tumor microenvironment is also known to enhance the signaling competence of α6β4 through functional and physical interactions with other receptors. In this review, we discuss the biological mechanisms by which integrin α6β4 promotes carcinoma cell motility and invasion that leads to mammary tumor progression.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21190525     DOI： 10.2174/138920311795659399

Source DB:  PubMed          Journal:  Curr Protein Pept Sci        ISSN： 1389-2037            Impact factor:   3.272


  15 in total

1.  Penfluridol: An Antipsychotic Agent Suppresses Metastatic Tumor Growth in Triple-Negative Breast Cancer by Inhibiting Integrin Signaling Axis.

Authors:  Alok Ranjan; Parul Gupta; Sanjay K Srivastava
Journal:  Cancer Res       Date:  2015-12-01       Impact factor: 12.701

2.  Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the α(6)β(4) integrin and MT1-MMP.

Authors:  Honoré Ngora; Uwe M Galli; Kaoru Miyazaki; Margot Zöller
Journal:  Neoplasia       Date:  2012-02       Impact factor: 5.715

Review 3.  Cancer cells remodel themselves and vasculature to overcome the endothelial barrier.

Authors:  Anitha K Shenoy; Jianrong Lu
Journal:  Cancer Lett       Date:  2014-10-31       Impact factor: 8.679

4.  MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway.

Authors:  Te-Hsuan Jang; Wei-Chieh Huang; Shiao-Lin Tung; Sheng-Chieh Lin; Po-Ming Chen; Chun-Yu Cho; Ya-Yu Yang; Tzu-Chen Yen; Guo-Hsuen Lo; Shuang-En Chuang; Lu-Hai Wang
Journal:  J Biomed Sci       Date:  2022-06-15       Impact factor: 12.771

Review 5.  Pancreatic cancer stem cell markers and exosomes - the incentive push.

Authors:  Sarah Heiler; Zhe Wang; Margot Zöller
Journal:  World J Gastroenterol       Date:  2016-07-14       Impact factor: 5.742

6.  SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells.

Authors:  X Zhou; L Matskova; L-S Z Rathje; X Xiao; G Gish; M Werner; I Ignatyev; N Yu; W Zhao; F Tian; B Hou; Z Zhang; T Pawson; F Chen; I Ernberg
Journal:  Oncogene       Date:  2014-12-22       Impact factor: 9.867

7.  Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody.

Authors:  Winn Aung; Atsushi B Tsuji; Hitomi Sudo; Aya Sugyo; Yoshinori Ukai; Katsushi Kouda; Yoshikazu Kurosawa; Takako Furukawa; Tsuneo Saga
Journal:  Oncotarget       Date:  2016-06-21

Review 8.  Laminin-511: a multi-functional adhesion protein regulating cell migration, tumor invasion and metastasis.

Authors:  Normand Pouliot; Nicole Kusuma
Journal:  Cell Adh Migr       Date:  2012-10-17       Impact factor: 3.405

9.  P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells.

Authors:  André Filipe Vieira; Ana Sofia Ribeiro; Maria Rita Dionísio; Bárbara Sousa; Ana Rita Nobre; André Albergaria; Angélica Santiago-Gómez; Nuno Mendes; Renê Gerhard; Fernando Schmitt; Robert B Clarke; Joana Paredes
Journal:  Oncotarget       Date:  2014-02-15

10.  Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling.

Authors:  Qi Chen; Rong Xu; Chunyan Zeng; Quqin Lu; Dengliang Huang; Chao Shi; Weilong Zhang; Libin Deng; Runwei Yan; Hai Rao; Guolan Gao; Shiwen Luo
Journal:  PLoS One       Date:  2014-02-12       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.