Literature DB >> 2118888

Induction of hepatic tumors with butylated hydroxyanisole in the self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus.

E H Park1, H H Chang, Y N Cha.   

Abstract

The three-day-old larvae of self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus were fed a diet containing the antioxidant butylated hydroxyanisole (BHA) at levels of 0.01-0.8% for 12 days. Six months after BHA administration, hepatic tumors were found in all groups of BHA-treated fish. The BHA-induced tumor incidences were clearly dose-dependent. These results show that dietary BHA is hepatocarcinogenic in Rivulus even at 0.01% dose.

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Year:  1990        PMID： 2118888      PMCID： PMC5918089          DOI： 10.1111/j.1349-7006.1990.tb02638.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  25 in total

1.  [Gastrointestinal absorption in the rat of anisole, trans-anethole, butylhydroxyanisole and safrole].

Authors:  P Fritsch; G de Saint Blanquat; R Derache
Journal:  Food Cosmet Toxicol       Date:  1975-06

2.  CHRONIC FEEDING STUDIES OF BUTYLATED HYDROXYANISOLE IN DOGS.

Authors:  H C HODGE; D W FASSETT; E A MAYNARD; W L DOWNS; R D COYE
Journal:  Toxicol Appl Pharmacol       Date:  1964-09       Impact factor: 4.219

3.  Induction of squamous cell carcinoma in the forestomach of F344 rats treated with butylated hydroxyanisole.

Authors:  N Ito; A Hagiwara; M Shibata; T Ogiso; S Fukushima
Journal:  Gan       Date:  1982-04

4.  Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice.

Authors:  G D Stoner; M B Shimkin; A J Kniazeff; J H Weisburger; E K Weisburger; G B Gori
Journal:  Cancer Res       Date:  1973-12       Impact factor: 12.701

Review 5.  Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants.

Authors:  N Ito; S Fukushima; H Tsuda
Journal:  Crit Rev Toxicol       Date:  1985       Impact factor: 5.635

6.  Metabolism of 3-tert-butyl-4-hydroxyanisole by microsomal fractions and isolated rat hepatocytes.

Authors:  S W Cummings; G A Ansari; F P Guengerich; L S Crouch; R A Prough
Journal:  Cancer Res       Date:  1985-11       Impact factor: 12.701

7.  Effect of subchronic dietary administration of butylated hydroxyanisole on canine stomach and hepatic tissue.

Authors:  G J Ikeda; J E Stewart; P P Sapienza; J O Peggins; T C Michel; V Olivito; H Z Alam; M W O'Donnell
Journal:  Food Chem Toxicol       Date:  1986 Oct-Nov       Impact factor: 6.023

8.  Hepatocarcinogenicity of diethylnitrosamine to the self-fertilizing hermaphroditic fish Rivulus marmoratus (Teleostomi: Cyprinodontidae).

Authors:  E H Park; D S Kim
Journal:  J Natl Cancer Inst       Date:  1984-10       Impact factor: 13.506

9.  Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole.

Authors:  Y N Cha; F Martz; E Bueding
Journal:  Cancer Res       Date:  1978-12       Impact factor: 12.701

10.  Comparative effects of dietary administration of 2(3)-tert-butyl-4-hydroxyanisole and 3,5-di-tert-butyl-4-hydroxytoluene on several hepatic enzyme activities in mice and rats.

Authors:  Y N Cha; H S Heine
Journal:  Cancer Res       Date:  1982-07       Impact factor: 12.701
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  2 in total

1.  Genetic composition of laboratory stocks of the self-fertilizing fish Kryptolebias marmoratus: a valuable resource for experimental research.

Authors:  Andrey Tatarenkov; Brian C Ring; John F Elder; David L Bechler; John C Avise
Journal:  PLoS One       Date:  2010-09-22       Impact factor: 3.240

2.  High frequency of thyroid tumor induction by N-methyl-N'-nitro-N-nitrosoguanidine in the hermaphroditic fish Rivulus marmoratus.

Authors:  E H Park; H H Chang; K C Lee; H S Kweon; O S Heo; K W Ha
Journal:  Jpn J Cancer Res       Date:  1993-06
  2 in total

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