Literature DB >> 21188557

Therapies targeting exogenous cholesterol uptake: new insights and controversies.

Michael H Davidson1.   

Abstract

Exogenous cholesterol uptake involves a complex process in the intestines for the absorption of cholesterol and bile acids. This process is regulated by intestinal nuclear transcription factors such as LXR that affect sterol transporters NPC1L1, ABCG5/G8, and ABCG1, and enzymes such as ACAT-2. Plant sterol/stanols, ezetimibe, and bile acid sequestrants have a variety of effects on these various transporters, and new insights into their mechanism(s) of action have provided a plethora of exciting targets for metabolic diseases, dyslipidemia, and atherosclerosis.

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Year:  2011        PMID： 21188557     DOI： 10.1007/s11883-010-0151-2

Source DB:  PubMed          Journal:  Curr Atheroscler Rep        ISSN： 1523-3804            Impact factor:   5.113


  43 in total

1.  Localization and role of NPC1L1 in cholesterol absorption in human intestine.

Authors:  Alain Théophile Sané; Daniel Sinnett; Edgard Delvin; Moise Bendayan; Valérie Marcil; Daniel Ménard; Jean-François Beaulieu; Emile Levy
Journal:  J Lipid Res       Date:  2006-07-07       Impact factor: 5.922

2.  Moderately decreased cholesterol absorption rates are associated with a large atheroprotective effect.

Authors:  Michael E Greenberg; Jonathan D Smith; Ephraim Sehayek
Journal:  Arterioscler Thromb Vasc Biol       Date:  2009-08-06       Impact factor: 8.311

3.  Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.

Authors:  Thierry Claudel; Ekkehard Sturm; Hélène Duez; Inés Pineda Torra; Audrey Sirvent; Vladimir Kosykh; Jean-Charles Fruchart; Jean Dallongeville; Dean W Hum; Folkert Kuipers; Bart Staels
Journal:  J Clin Invest       Date:  2002-04       Impact factor: 14.808

4.  Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8.

Authors:  Knut E Berge; Klaus von Bergmann; Dieter Lutjohann; Rudy Guerra; Scott M Grundy; Helen H Hobbs; Jonathan C Cohen
Journal:  J Lipid Res       Date:  2002-03       Impact factor: 5.922

5.  Ezetimibe prevents cholesterol gallstone formation in mice.

Authors:  Silvia Zúñiga; Héctor Molina; Lorena Azocar; Ludwig Amigo; Flavio Nervi; Fernando Pimentel; Nicolás Jarufe; Marco Arrese; Frank Lammert; Juan F Miquel
Journal:  Liver Int       Date:  2008-08       Impact factor: 5.828

6.  Effect of structure and form on the ability of plant sterols to inhibit cholesterol absorption in hamsters.

Authors:  Gert W Meijer; Marco A J J Bressers; W Arjan de Groot; Mike Rudrum
Journal:  Lipids       Date:  2003-07       Impact factor: 1.880

7.  Cholesterol absorption from the intestine is a major determinant of reverse cholesterol transport from peripheral tissue macrophages.

Authors:  Ephraim Sehayek; Stanley L Hazen
Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-04-17       Impact factor: 8.311

8.  Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial.

Authors:  L Jakulj; M N Vissers; A K Groen; B A Hutten; D Lutjohann; E P Veltri; J J P Kastelein
Journal:  J Lipid Res       Date:  2009-10-14       Impact factor: 5.922

9.  Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo.

Authors:  Xun Wang; Heidi L Collins; Mollie Ranalletta; Ilia V Fuki; Jeffrey T Billheimer; George H Rothblat; Alan R Tall; Daniel J Rader
Journal:  J Clin Invest       Date:  2007-08       Impact factor: 14.808

10.  Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1.

Authors:  Quan Shang; Monica Saumoy; Jens Juul Holst; Gerald Salen; Guorong Xu
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-12-31       Impact factor: 4.052
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  1 in total

1.  Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice.

Authors:  Diana M Shih; Zory Shaposhnik; Yonghong Meng; Melenie Rosales; Xuping Wang; Judy Wu; Boris Ratiner; Filiberto Zadini; Giorgio Zadini; Aldons J Lusis
Journal:  FASEB J       Date:  2013-06-10       Impact factor: 5.191
  1 in total

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