Literature DB >> 21188555

Coreceptors and HIV-1 pathogenesis.

Paul R Gorry1, Petronela Ancuta.   

Abstract

The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and are therefore a critical component of the HIV-1 life cycle. Alterations in coreceptor preference as well as the efficiency and mechanism of interaction between HIV-1 and CCR5 and/or CXCR4 has a significant influence on viral tropism, progression of disease, and response to coreceptor antagonists. In addition, these alterations influence the susceptibility of CD4+ T-cell, monocyte, and dendritic cell subsets to infection and therefore, are important for several facets of HIV-1 pathogenesis including the establishment of latent reservoirs, trafficking, and transmission. This review highlights recent literature that has advanced our understanding of the role of coreceptors in HIV-1 pathogenesis.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21188555     DOI： 10.1007/s11904-010-0069-x

Source DB:  PubMed          Journal:  Curr HIV/AIDS Rep        ISSN： 1548-3568            Impact factor:   5.071


  49 in total

1.  Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors.

Authors:  Jonathan Toma; Jeannette M Whitcomb; Christos J Petropoulos; Wei Huang
Journal:  AIDS       Date:  2010-09-10       Impact factor: 4.177

2.  The precursors of memory: models and controversies.

Authors:  Rafi Ahmed; Michael J Bevan; Steven L Reiner; Douglas T Fearon
Journal:  Nat Rev Immunol       Date:  2009-08-14       Impact factor: 53.106

Review 3.  Targeting early infection to prevent HIV-1 mucosal transmission.

Authors:  Ashley T Haase
Journal:  Nature       Date:  2010-03-11       Impact factor: 49.962

4.  Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry.

Authors:  Mike Westby; Caroline Smith-Burchnell; Julie Mori; Marilyn Lewis; Michael Mosley; Mark Stockdale; Patrick Dorr; Giuseppe Ciaramella; Manos Perros
Journal:  J Virol       Date:  2006-12-20       Impact factor: 5.103

5.  Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.

Authors:  M Samson; F Libert; B J Doranz; J Rucker; C Liesnard; C M Farber; S Saragosti; C Lapoumeroulie; J Cognaux; C Forceille; G Muyldermans; C Verhofstede; G Burtonboy; M Georges; T Imai; S Rana; Y Yi; R J Smyth; R G Collman; R W Doms; G Vassart; M Parmentier
Journal:  Nature       Date:  1996-08-22       Impact factor: 49.962

Review 6.  The neuropathogenesis of AIDS.

Authors:  Francisco González-Scarano; Julio Martín-García
Journal:  Nat Rev Immunol       Date:  2005-01       Impact factor: 53.106

7.  Quantitative 3D video microscopy of HIV transfer across T cell virological synapses.

Authors:  Wolfgang Hübner; Gregory P McNerney; Ping Chen; Benjamin M Dale; Ronald E Gordon; Frank Y S Chuang; Xiao-Dong Li; David M Asmuth; Thomas Huser; Benjamin K Chen
Journal:  Science       Date:  2009-03-27       Impact factor: 47.728

8.  HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Authors:  Nicolas Chomont; Mohamed El-Far; Petronela Ancuta; Lydie Trautmann; Francesco A Procopio; Bader Yassine-Diab; Geneviève Boucher; Mohamed-Rachid Boulassel; Georges Ghattas; Jason M Brenchley; Timothy W Schacker; Brenna J Hill; Daniel C Douek; Jean-Pierre Routy; Elias K Haddad; Rafick-Pierre Sékaly
Journal:  Nat Med       Date:  2009-06-21       Impact factor: 53.440

9.  Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission.

Authors:  Fedde Groot; Toni M M van Capel; Joost Schuitemaker; Ben Berkhout; Esther C de Jong
Journal:  Retrovirology       Date:  2006-08-17       Impact factor: 4.602

10.  Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients.

Authors:  Petronela Ancuta; Anupa Kamat; Kevin J Kunstman; Eun-Young Kim; Patrick Autissier; Alysse Wurcel; Tauheed Zaman; David Stone; Megan Mefford; Susan Morgello; Elyse J Singer; Steven M Wolinsky; Dana Gabuzda
Journal:  PLoS One       Date:  2008-06-25       Impact factor: 3.240
View more
  68 in total

Review 1.  Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injury.

Authors:  Ricky Maung; Kathryn E Medders; Natalia E Sejbuk; Maya K Desai; Rossella Russo; Marcus Kaul
Journal:  J Neuroimmune Pharmacol       Date:  2011-11-29       Impact factor: 4.147

2.  Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages.

Authors:  Kieran Cashin; Michael Roche; Jasminka Sterjovski; Anne Ellett; Lachlan R Gray; Anthony L Cunningham; Paul A Ramsland; Melissa J Churchill; Paul R Gorry
Journal:  J Virol       Date:  2011-08-10       Impact factor: 5.103

3.  Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism.

Authors:  Olivia O'Connell; Alexander Repik; Jacqueline D Reeves; Maria Paz Gonzalez-Perez; Briana Quitadamo; Elizabeth D Anton; Maria Duenas-Decamp; Paul Peters; Rongheng Lin; Susan Zolla-Pazner; Davide Corti; Aaron Wallace; Shixia Wang; Xiang-Peng Kong; Shan Lu; Paul R Clapham
Journal:  J Virol       Date:  2012-10-10       Impact factor: 5.103

4.  A GxxxG-like motif within HIV-1 fusion peptide is critical to its immunosuppressant activity, structure, and interaction with the transmembrane domain of the T-cell receptor.

Authors:  Omri Faingold; Tomer Cohen; Yechiel Shai
Journal:  J Biol Chem       Date:  2012-08-07       Impact factor: 5.157

5.  A novel approach to block HIV-1 coreceptor CXCR4 in non-toxic manner.

Authors:  Ye Liu; Jieqiong Zhou; Ji-An Pan; Prudence Mabiala; Deyin Guo
Journal:  Mol Biotechnol       Date:  2014-10       Impact factor: 2.695

6.  HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism.

Authors:  Michael Roche; Martin R Jakobsen; Jasminka Sterjovski; Anne Ellett; Filippo Posta; Benhur Lee; Becky Jubb; Mike Westby; Sharon R Lewin; Paul A Ramsland; Melissa J Churchill; Paul R Gorry
Journal:  J Virol       Date:  2011-02-23       Impact factor: 5.103

7.  Macrophages sustain HIV replication in vivo independently of T cells.

Authors:  Jenna B Honeycutt; Angela Wahl; Caroline Baker; Rae Ann Spagnuolo; John Foster; Oksana Zakharova; Stephen Wietgrefe; Carolina Caro-Vegas; Victoria Madden; Garrett Sharpe; Ashley T Haase; Joseph J Eron; J Victor Garcia
Journal:  J Clin Invest       Date:  2016-03-07       Impact factor: 14.808

8.  Neuronal toxicity in HIV CNS disease.

Authors:  Jane Kovalevich; Dianne Langford
Journal:  Future Virol       Date:  2012-07-01       Impact factor: 1.831

9.  Profile of HIV type 1 coreceptor tropism among Kenyan patients from 2009 to 2010.

Authors:  Anthony Kebira Nyamache; Anne W T Muigai; Zipporah Ng'ang'a; Samoel A Khamadi
Journal:  AIDS Res Hum Retroviruses       Date:  2013-05-21       Impact factor: 2.205

10.  Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5.

Authors:  Hamid Salimi; Michael Roche; Nicholas Webb; Lachlan R Gray; Kelechi Chikere; Jasminka Sterjovski; Anne Ellett; Steve L Wesselingh; Paul A Ramsland; Benhur Lee; Melissa J Churchill; Paul R Gorry
Journal:  J Leukoc Biol       Date:  2012-10-17       Impact factor: 4.962
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.