BACKGROUND/AIM: Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro. However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric cancer (GC). PATIENTS AND METHODS: A total of 265 GCs were examined by immunofluorescent staining with antibodies against vimentin and carcinoembryonic antigen. GCs were determined to be vimentin-positive when cells were positive for both vimentin and carcinoembryonic antigen staining. RESULTS: A total of 86 (32%) of 265 GCs were vimentin positive. There was a statistically significant correlation between vimentin-positive GCs and advanced clinical stage (p<0.001), macroscopic scirrhous-type (p < 0.001), histological diffuse-type (p < 0.001), lymph node metastasis (p = 0.008) and lymphatic invasion (p = 0.013). The prognosis of patients with vimentin-positive GCs was significantly (p < 0.001) worse than that with vimentin-negative GCs. CONCLUSION: Vimentin expression might contribute to the high invasive phenotype of GC, and may be a useful biomarker to determine the biological aggressiveness of GC.
BACKGROUND/AIM: Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro. However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric cancer (GC). PATIENTS AND METHODS: A total of 265 GCs were examined by immunofluorescent staining with antibodies against vimentin and carcinoembryonic antigen. GCs were determined to be vimentin-positive when cells were positive for both vimentin and carcinoembryonic antigen staining. RESULTS: A total of 86 (32%) of 265 GCs were vimentin positive. There was a statistically significant correlation between vimentin-positive GCs and advanced clinical stage (p<0.001), macroscopic scirrhous-type (p < 0.001), histological diffuse-type (p < 0.001), lymph node metastasis (p = 0.008) and lymphatic invasion (p = 0.013). The prognosis of patients with vimentin-positive GCs was significantly (p < 0.001) worse than that with vimentin-negative GCs. CONCLUSION:Vimentin expression might contribute to the high invasive phenotype of GC, and may be a useful biomarker to determine the biological aggressiveness of GC.
Authors: Tatyana N Zamay; Olga S Kolovskaya; Yury E Glazyrin; Galina S Zamay; Svetlana A Kuznetsova; Ekaterina A Spivak; Mohamed Wehbe; Anna G Savitskaya; Olga A Zubkova; Anastasia Kadkina; Xiaoyan Wang; Darija Muharemagic; Anna Dubynina; Yuliya Sheina; Alla B Salmina; Maxim V Berezovski; Anna S Zamay Journal: Nucleic Acid Ther Date: 2014-01-11 Impact factor: 5.486
Authors: Hongyu Wang; Xin Li; David E Volk; Ganesh L-R Lokesh; Miguel-Angel Elizondo-Riojas; Li Li; Alpa M Nick; Anil K Sood; Kevin P Rosenblatt; David G Gorenstein Journal: Biotechniques Date: 2016-11-01 Impact factor: 1.993