Kristoffer Derwinger1, Karl Kodeda, Roger Gerjy. 1. Sahlgrenska Academy/Department of Surgery, Sahlgrenska University Hospital/Östra, 41685 Gothenburg, Sweden. kristoffer.derwinger@vgregion.se
Abstract
AIM: The aim of this study was to assess how age is related to differences in stage, tumour differentiation and treatment in colorectal cancer. PATIENTS AND METHODS: A retrospective study in a consecutive series of colorectal cancer patients (n = 2220) where age was related to demography, stage, tumour characteristics, treatment and outcome (OS/CSS) both as a continuous variable and grouped by high/low 10th percentiles, as young/old groups, with a third median reference group. RESULTS: Young patients had more advanced cancer stages (p = 0.012), higher N-status (p = 0.011) and more frequent T4/G4 tumours. Old patients had higher postoperative mortality and were less likely to receive chemotherapy. The proportion of cancer-related deaths was stage-dependent and decreased with age. CONCLUSION: Cancer stage, tumour characteristics, treatment and outcome can vary with age in colorectal cancer. The increasing proportion of non-cancer deaths at a higher age can affect the use of overall survival as an outcome parameter, which may be of importance in evaluating clinical and translational research.
AIM: The aim of this study was to assess how age is related to differences in stage, tumour differentiation and treatment in colorectal cancer. PATIENTS AND METHODS: A retrospective study in a consecutive series of colorectal cancerpatients (n = 2220) where age was related to demography, stage, tumour characteristics, treatment and outcome (OS/CSS) both as a continuous variable and grouped by high/low 10th percentiles, as young/old groups, with a third median reference group. RESULTS: Young patients had more advanced cancer stages (p = 0.012), higher N-status (p = 0.011) and more frequent T4/G4 tumours. Old patients had higher postoperative mortality and were less likely to receive chemotherapy. The proportion of cancer-related deaths was stage-dependent and decreased with age. CONCLUSION:Cancer stage, tumour characteristics, treatment and outcome can vary with age in colorectal cancer. The increasing proportion of non-cancer deaths at a higher age can affect the use of overall survival as an outcome parameter, which may be of importance in evaluating clinical and translational research.
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