BACKGROUND: The Mus81 gene encodes a critical endonuclease involved in DNA repair and tumor suppression. In the present study, the role of Mus81 in gastric cancer was explored. MATERIALS AND METHODS: Mus81 expression in 53 cases of gastric cancer and the corresponding normal tissues was determined by quantitative real-time PCR. The correlations between Mus81 down-regulation and the clinicopathological data were also evaluated. RESULTS: Mus81 expression was significantly lower in gastric cancer tissues than the corresponding normal tissues (p = 0.018) and the down-regulation of Mus81 occurred in 51% (27/53) of the gastric carcinomas. More importantly, Mus81 down-regulation correlated significantly to invasion depth (p = 0.015) and poorly-differentiated type (p = 0.016) of gastric cancer. CONCLUSION: Mus81 might be a potential marker for the malignancy of gastric cancer.
BACKGROUND: The Mus81 gene encodes a critical endonuclease involved in DNA repair and tumor suppression. In the present study, the role of Mus81 in gastric cancer was explored. MATERIALS AND METHODS:Mus81 expression in 53 cases of gastric cancer and the corresponding normal tissues was determined by quantitative real-time PCR. The correlations between Mus81 down-regulation and the clinicopathological data were also evaluated. RESULTS:Mus81 expression was significantly lower in gastric cancer tissues than the corresponding normal tissues (p = 0.018) and the down-regulation of Mus81 occurred in 51% (27/53) of the gastric carcinomas. More importantly, Mus81 down-regulation correlated significantly to invasion depth (p = 0.015) and poorly-differentiated type (p = 0.016) of gastric cancer. CONCLUSION:Mus81 might be a potential marker for the malignancy of gastric cancer.
Authors: S El Ghamrasni; R Cardoso; L Li; K K N Guturi; V A Bjerregaard; Y Liu; S Venkatesan; M P Hande; J T Henderson; O Sanchez; I D Hickson; A Hakem; R Hakem Journal: Oncogene Date: 2016-02-15 Impact factor: 9.867
Authors: Yuan Lin; Harvind S Chahal; Wenting Wu; Hyunje G Cho; Katherine J Ransohoff; Fengju Song; Jean Y Tang; Kavita Y Sarin; Jiali Han Journal: Int J Cancer Date: 2017-05-31 Impact factor: 7.396
Authors: Irene Saugar; María Victoria Vázquez; María Gallo-Fernández; María Ángeles Ortiz-Bazán; Mónica Segurado; Arturo Calzada; José Antonio Tercero Journal: Nucleic Acids Res Date: 2013-07-30 Impact factor: 16.971
Authors: T P MacGregor; R Carter; R S Gillies; J M Findlay; C Kartsonaki; F Castro-Giner; N Sahgal; L M Wang; R Chetty; N D Maynard; J B Cazier; F Buffa; P J McHugh; I Tomlinson; M R Middleton; R A Sharma Journal: Sci Rep Date: 2018-05-08 Impact factor: 4.379