Literature DB >> 21186393

Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone.

Alejandro F Barrero1, M Mar Herrador, José F Quílez del Moral, Pilar Arteaga, Niklas Meine, M Carmen Pérez-Morales, Julieta V Catalán.   

Abstract

Highly efficient preparations of anticancer β-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3-5 steps with excellent overall yields (43-54%). An enantioselective approach to these molecules is also described.

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Year:  2010        PMID： 21186393     DOI： 10.1039/c0ob00467g

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  10 in total

1.  HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis.

Authors:  Dan Liang; Maowei Yang; Baolei Guo; Lei Yang; Junjun Cao; Xiuli Zhang
Journal:  J Cancer Res Clin Oncol       Date:  2012-06-27       Impact factor: 4.553

2.  Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H2O2-Induced Apoptosis.

Authors:  Jichao Chen; Ruifan Wang; Tianyu Wang; Qilong Ding; Aliahmad Khalil; Shengtao Xu; Aijun Lin; Hequan Yao; Weijia Xie; Zheying Zhu; Jinyi Xu
Journal:  ACS Med Chem Lett       Date:  2017-03-13       Impact factor: 4.345

3.  Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway.

Authors:  Yun-Yi Liu; Qian Zheng; Bin Fang; Wei Wang; Feng-Yun Ma; Sadia Roshan; Amal Banafa; Ming-Jie Chen; Jun-Li Chang; Xiao-Min Deng; Ke-Xiu Li; Guang-Xiao Yang; Guang-Yuan He
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2013-06-17

4.  β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.

Authors:  Xiaoqiang Li; Zhenhai Lin; Bo Zhang; Lei Guo; Shuang Liu; Hui Li; Jubo Zhang; Qinghai Ye
Journal:  Sci Rep       Date:  2016-02-12       Impact factor: 4.379

5.  Screening of NO Inhibitor Release Activity from Soft Coral Extracts Origin Palu Bay, Central Sulawesi, Indonesia.

Authors:  Wendy Alexander Tanod; Uun Yanuhar; Masteria Yunovilsa Putra; Yenny Risjani
Journal:  Antiinflamm Antiallergy Agents Med Chem       Date:  2019

6.  Co-Encapsulation of Mitoxantrone and β-Elemene in Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Leukemia.

Authors:  Kambere Amerigos Daddy J C; Minglei Chen; Faisal Raza; Yanyu Xiao; Zhigui Su; Qineng Ping
Journal:  Pharmaceutics       Date:  2020-02-23       Impact factor: 6.321

7.  Asymmetric total synthesis of (1S,2S,4S)-β-elemene.

Authors:  Wei Chen; Zhun Feng; Qiang Liu
Journal:  RSC Adv       Date:  2022-03-15       Impact factor: 3.361

8.  The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation.

Authors:  Li-Tian Ma; Yang Bai; Peng Cao; Kai-Xi Ren; Jing Chen; Ting Zhang; Bo-Yuan Fan; Yu Qiao; Hong-Yu Yan; Jing-Jie Wang; Yun-Qing Li; Jin Zheng
Journal:  Mol Pain       Date:  2022-04       Impact factor: 3.370

9.  Novel hydroxyl carboximates derived from β-elemene: design, synthesis and anti-tumour activities evaluation.

Authors:  Yuan Gao; Nian-Dong Mao; Hao Che; Li Xu; Renren Bai; Li-Wei Wang; Xiang-Yang Ye; Tian Xie
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

10.  β-Elemene derivatives produced from SeO2-mediated oxidation reaction.

Authors:  Xingrui He; Xiao-Tao Zhuo; Yuan Gao; Renren Bai; Xiang-Yang Ye; Tian Xie
Journal:  R Soc Open Sci       Date:  2020-05-13       Impact factor: 2.963
  10 in total

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