| Literature DB >> 2118635 |
A Yamamoto1, T Kawaratani, K Kawashima, M Hashida, H Sezaki.
Abstract
Intestinal transport of sulfanilic acid was examined by means of an in vitro everted sac technique in rats immunized with a bovine gamma-globulin-sulfanilic acid conjugate. At a low concentration of sulfanilic acid, the intestinal transport of sulfanilic acid was decreased in rats immunized with bovine gamma-globulin-sulfanilic acid conjugate. This phenomenon was dose dependent and antigen specific, since there was no difference in the transport of sulfanilic acid at a high concentration and of an unrelated hapten. These results suggested that parenteral immunization impaired not only the intestinal transport of macromolecular antigens, as previously shown, but also the transport of the low molecular weight hapten, sulfanilic acid.Entities:
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Year: 1990 PMID： 2118635 DOI： 10.1023/a:1015832009217
Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200