| Literature DB >> 21186095 |
R B Giordani1, D P Araújo, M Duarte, J A Zuanazzi, T Tasca, M V De Almeida.
Abstract
Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20μg/mL. N-hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T. vaginalis with MIC of 2.5μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti-G. lamblia activity than MTZ.Entities:
Mesh：
Substances：
Year: 2010 PMID： 21186095 DOI： 10.1016/j.biopha.2010.10.006
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529