| Literature DB >> 21185722 |
Daniel Simard1, Yves Leblanc, Carl Berthelette, M Helmi Zaghdane, Carmela Molinaro, Zhaoyin Wang, Michel Gallant, Stephen Lau, Trinh Thao, Martine Hamel, Rino Stocco, Nicole Sawyer, Susan Sillaots, Francois Gervais, Robert Houle, Jean-François Lévesque.
Abstract
A new class of 7-azaindole analogs of MK-7246 as potent and selective CRTH2 antagonists is reported. The SAR leading to the identification of the optimal azaindole regioisomer as well as the pharmacokinetics and off-target activities of the most potent antagonists are disclosed. Copyright ÂEntities:
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Year: 2010 PMID： 21185722 DOI： 10.1016/j.bmcl.2010.11.084
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823