Y Song1, K Lee, J Sung, D Lee, M K Lee, J Y Lee. 1. Department of Family Medicine, Samsung Medical Center and Center for Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 50 Irwondong, Gangnamgu, Seoul 135-710, South Korea.
Abstract
BACKGROUND AND AIMS: We examined heritability and bivariate analyses for the Framingham Risk Score (FRS) and adiposity measures among Koreans. METHODS AND RESULTS: We analysed the data from 2496 participants (962 men, 1534 women, age 30-74 years), including 1320 non-twin family members, 468 monozygotic (MZ) and 120 dizygotic (DZ) twin pairs, collected from the Healthy Twin study of Korea. Adiposity measurements comprised BMI, waist circumference (WC), waist-to-hip ratio and waist-to-height ratio (WHTR). Analyses were conducted using the Sequential Oligogenic Linkage Analysis Routines (SOLAR) package software. The co-twin control analyses shows that estimates of within-pair regression coefficients in the relationship between adiposity traits and FRS were attenuated for MZ twin pairs, relative to DZ twin pairs (0.11-0.26 vs. 0.60-0.71). The heritability estimate for FRS was 0.37, and the estimates for adiposity traits ranged from 0.45 to 0.63 (P < 0.001). Bivariate analysis revealed genetic correlations between FRS, and all of the adiposity traits ranged from 0.16 (for WHTR, P > 0.05) to 0.46 (for WC, P < 0.001). The common environmental correlations between FRS and each of the adiposity traits ranged from 0.43 to 0.66 (P < 0.001). CONCLUSIONS: FRS and each of the obesity traits shared common genetic and environmental relationships. These findings support a pleiotropic action between genes associated with adiposity traits and FRS and a need of further investigations for identifying specific common environmental factors.
BACKGROUND AND AIMS: We examined heritability and bivariate analyses for the Framingham Risk Score (FRS) and adiposity measures among Koreans. METHODS AND RESULTS: We analysed the data from 2496 participants (962 men, 1534 women, age 30-74 years), including 1320 non-twin family members, 468 monozygotic (MZ) and 120 dizygotic (DZ) twin pairs, collected from the Healthy Twin study of Korea. Adiposity measurements comprised BMI, waist circumference (WC), waist-to-hip ratio and waist-to-height ratio (WHTR). Analyses were conducted using the Sequential Oligogenic Linkage Analysis Routines (SOLAR) package software. The co-twin control analyses shows that estimates of within-pair regression coefficients in the relationship between adiposity traits and FRS were attenuated for MZ twin pairs, relative to DZ twin pairs (0.11-0.26 vs. 0.60-0.71). The heritability estimate for FRS was 0.37, and the estimates for adiposity traits ranged from 0.45 to 0.63 (P < 0.001). Bivariate analysis revealed genetic correlations between FRS, and all of the adiposity traits ranged from 0.16 (for WHTR, P > 0.05) to 0.46 (for WC, P < 0.001). The common environmental correlations between FRS and each of the adiposity traits ranged from 0.43 to 0.66 (P < 0.001). CONCLUSIONS: FRS and each of the obesity traits shared common genetic and environmental relationships. These findings support a pleiotropic action between genes associated with adiposity traits and FRS and a need of further investigations for identifying specific common environmental factors.
Authors: Gemma Cadby; Phillip E Melton; Nina S McCarthy; Marcio Almeida; Sarah Williams-Blangero; Joanne E Curran; John L VandeBerg; Jennie Hui; John Beilby; A W Musk; Alan L James; Joseph Hung; John Blangero; Eric K Moses Journal: Hum Genet Date: 2017-11-27 Impact factor: 4.132
Authors: Y J Sung; L Pérusse; M A Sarzynski; M Fornage; S Sidney; B Sternfeld; T Rice; J G Terry; D R Jacobs; P Katzmarzyk; J E Curran; J Jeffrey Carr; J Blangero; S Ghosh; J-P Després; T Rankinen; D C Rao; C Bouchard Journal: Int J Obes (Lond) Date: 2015-10-20 Impact factor: 5.551