Xiao Huang1, Jiangpei Zhao, Tongfeng Zhao. 1. College of Life Sciences, Zhejiang University, and Department of GEriatrics, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310000, China.
Abstract
OBJECTIVE: Results from the published studies on the association of peroxisome proliferator activated receptor-gamma 2 (PPARγ2) Pro12Ala polymorphism with blood lipids are conflicting. In this meta-analysis, we investigated the association of the Pro12Ala polymorphism with total cholesterol, triglycerides, low density lipoprotein cholesterol, and high-density lipoprotein cholesterol. METHODS: 74 studies with 52,998 subjects were included in this meta-analysis. Dominant model and additive model were used for this meta-analysis. RESULTS: We did not detect significant overall association of the Pro12Ala polymorphism with total cholesterol, low density lipoprotein cholesterol, or high-density lipoprotein cholesterol (P>0.05). Under dominant model, significant association between the PPARγ2 Pro12Ala polymorphism and increased blood TC in male subjects was detected: standardized mean difference=0.10, 95% confidence interval (0.02, 0.22), P=0.02, Pheterogeneity=0.14. We found a marginal association of the Pro12Ala polymorphism with increased HDL-C in healthy subjects under dominant model: standardized mean difference=0.10, 95% confidence interval (-0.00, 0.20), P=0.06, Pheterogeneity=0.96. We also found subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians: for analysis including the outlier studies: SMD=-0.40, 95% CI (-0.76, -0.05), P=0.02, Pheterogeneity<0.00001, and for analysis excluding the outlier studies: SMD=-0.23, 95% CI (-0.39, -0.06), P=0.006, Pheterogeneity=0.86. CONCLUSIONS: Our meta-analysis suggests that, compared with non-carriers, carriers of Ala allele have significant increased blood TC in male subjects, and marginally significant increased blood HDL-C in healthy subjects. Our meta-analysis also supports that subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians.
OBJECTIVE: Results from the published studies on the association of peroxisome proliferator activated receptor-gamma 2 (PPARγ2) Pro12Ala polymorphism with blood lipids are conflicting. In this meta-analysis, we investigated the association of the Pro12Ala polymorphism with total cholesterol, triglycerides, low density lipoprotein cholesterol, and high-density lipoprotein cholesterol. METHODS: 74 studies with 52,998 subjects were included in this meta-analysis. Dominant model and additive model were used for this meta-analysis. RESULTS: We did not detect significant overall association of the Pro12Ala polymorphism with total cholesterol, low density lipoprotein cholesterol, or high-density lipoprotein cholesterol (P>0.05). Under dominant model, significant association between the PPARγ2 Pro12Ala polymorphism and increased blood TC in male subjects was detected: standardized mean difference=0.10, 95% confidence interval (0.02, 0.22), P=0.02, Pheterogeneity=0.14. We found a marginal association of the Pro12Ala polymorphism with increased HDL-C in healthy subjects under dominant model: standardized mean difference=0.10, 95% confidence interval (-0.00, 0.20), P=0.06, Pheterogeneity=0.96. We also found subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians: for analysis including the outlier studies: SMD=-0.40, 95% CI (-0.76, -0.05), P=0.02, Pheterogeneity<0.00001, and for analysis excluding the outlier studies: SMD=-0.23, 95% CI (-0.39, -0.06), P=0.006, Pheterogeneity=0.86. CONCLUSIONS: Our meta-analysis suggests that, compared with non-carriers, carriers of Ala allele have significant increased blood TC in male subjects, and marginally significant increased blood HDL-C in healthy subjects. Our meta-analysis also supports that subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians.
Authors: Jussi Pihlajamäki; Ursula Schwab; Dorota Kaminska; Jyrki Ågren; Johanna Kuusisto; Marjukka Kolehmainen; Jussi Paananen; Markku Laakso; Matti Uusitupa Journal: Genes Nutr Date: 2015-10-07 Impact factor: 5.523
Authors: Pilar García-Broncano; Juan Berenguer; Amanda Fernández-Rodríguez; Daniel Pineda-Tenor; María Ángeles Jiménez-Sousa; Mónica García-Alvarez; Pilar Miralles; Teresa Aldámiz-Echevarria; Juan Carlos López; Dariela Micheloud; Salvador Resino Journal: J Transl Med Date: 2014-08-27 Impact factor: 5.531