| Literature DB >> 21185406 |
Matteo Bulati1, Silvio Buffa, Giuseppina Candore, Calogero Caruso, Deborah K Dunn-Walters, Mariavaleria Pellicanò, Yu-Chang Wu, Giuseppina Colonna Romano.
Abstract
Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly.Entities:
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Year: 2010 PMID： 21185406 DOI： 10.1016/j.arr.2010.12.002
Source DB: PubMed Journal: Ageing Res Rev ISSN： 1568-1637 Impact factor: 10.895