Literature DB >> 21185289

The LKB1/AMPK polarity pathway.

Vincent Mirouse1, Marc Billaud.   

Abstract

The LKB1 tumor suppressor kinase is an activator of the AMP-activated protein kinase (AMPK), a metabolic gauge that responds to variations of cellular energetic levels by favoring catabolic versus anabolic processes. Recent studies have provided substantial evidence that LKB1 and AMPK control cell polarity from invertebrates to mammals. This review examines how the LKB1-AMPK pathway, in conjunction with other positional signals, converts energy-sensing information into the activation of Myosin II to maintain epithelial-cell architecture but also to complete cell division. This molecular link between polarity and metabolism may constitute an ancient stress-response protective mechanism that was co-opted for tumor suppression during evolution.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 21185289     DOI： 10.1016/j.febslet.2010.12.025

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  31 in total

Review 1.  Epithelial cell polarity, stem cells and cancer.

Authors:  Fernando Martin-Belmonte; Mirna Perez-Moreno
Journal:  Nat Rev Cancer       Date:  2011-12-15       Impact factor: 60.716

2.  Flavonoids in propolis acting on mast cell-mediated wound healing.

Authors:  Salvatore Chirumbolo
Journal:  Inflammopharmacology       Date:  2012-02-17       Impact factor: 4.473

3.  Cellular polarity in aging: role of redox regulation and nutrition.

Authors:  Helena Soares; H Susana Marinho; Carla Real; Fernando Antunes
Journal:  Genes Nutr       Date:  2013-12-04       Impact factor: 5.523

4.  Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress.

Authors:  Alan Bolnick; Mohammed Abdulhasan; Brian Kilburn; Yufen Xie; Mindie Howard; Paul Andresen; Alexandra M Shamir; Jing Dai; Elizabeth E Puscheck; Eric Secor; Daniel A Rappolee
Journal:  J Assist Reprod Genet       Date:  2017-09-15       Impact factor: 3.412

5.  Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.

Authors:  Benjamin D Stein; Diego Calzolari; Kristina Hellberg; Ying S Hu; Lin He; Chien-Min Hung; Erin Q Toyama; Debbie S Ross; Björn F Lillemeier; Lewis C Cantley; John R Yates; Reuben J Shaw
Journal:  Cell Rep       Date:  2019-12-03       Impact factor: 9.423

6.  Connecting metabolism to intestinal barrier function: The role of leptin.

Authors:  Gwenola Le Dréan; Jean-Pierre Segain
Journal:  Tissue Barriers       Date:  2014-08-08

Review 7.  The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.

Authors:  Maria M Mihaylova; Reuben J Shaw
Journal:  Nat Cell Biol       Date:  2011-09-02       Impact factor: 28.824

8.  Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation.

Authors:  Huaiping Zhu; Cate M Moriasi; Miao Zhang; Yu Zhao; Ming-Hui Zou
Journal:  J Biol Chem       Date:  2013-04-23       Impact factor: 5.157

9.  Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.

Authors:  Juan Li; Jie Liu; Pingping Li; Xiaona Mao; Wenjie Li; Jin Yang; Peijun Liu
Journal:  J Exp Clin Cancer Res       Date:  2014-09-02

10.  LKB1 and AMPK regulate synaptic remodeling in old age.

Authors:  Melanie A Samuel; P Emanuela Voinescu; Brendan N Lilley; Rafa de Cabo; Marc Foretz; Benoit Viollet; Basil Pawlyk; Michael A Sandberg; Demetrios G Vavvas; Joshua R Sanes
Journal:  Nat Neurosci       Date:  2014-08-03       Impact factor: 24.884
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