| Literature DB >> 21185262 |
Balaji Babu1, Yang Liu, Adam Plaunt, Camille Riddering, Ross Ogilvie, Laura Westrate, Ryan Davis, Amanda Ferguson, Hilary Mackay, Toni Rice, Sameer Chavda, David Wilson, Shicai Lin, Konstantinos Kiakos, John A Hartley, Moses Lee.
Abstract
An orthogonally positioned diamino/dicationic polyamide f-IPI 2 was synthesized. It has enhanced binding affinity, and it showed comparable sequence specificity to its monoamino/monocationic counterpart f-IPI 1. Results from CD and DNase I footprinting studies confirmed the minor groove binding and selectivity of polyamides 1 and 2 for the cognate sequence 5'-ACGCGT-3'. SPR studies provided their binding constants: 2.4 × 10(8)M(-1) for diamino 2, which is ∼4 times higher than 5.4 × 10(7)M(-1) for its monoamino analogue 1.Entities:
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Year: 2010 PMID： 21185262 DOI： 10.1016/j.bbrc.2010.12.073
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575