Literature DB >> 21185185

The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties.

Jason E Imbriglio1, Daniel DiRocco, Rena Bodner, Subharekha Raghavan, Weichun Chen, Daria Marley, Craig Esser, Tom G Holt, Michael S Wolff, Andrew K P Taggart, M Gerard Waters, James R Tata, Steven L Colletti.   

Abstract

Amino-anthranilic acid derivatives have been identified as a new class of low serum shifted, high affinity full agonists of the human orphan G-protein-coupled receptor GPR109a with improved ADME properties.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 21185185     DOI: 10.1016/j.bmcl.2010.11.116

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  One-pot synthesis of densely functionalized cyclic β-aminoesters containing four stereocenters, based on a Et3N-promoted pseudo five-component reaction.

Authors:  Juan Yao; Lanxiang Zhou; Chen Tan; Cunde Wang
Journal:  Mol Divers       Date:  2014-09-26       Impact factor: 2.943

  1 in total

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