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Literature DB >> 21185169

Frontiers in targeting glioma stem cells.

Abstract

Patients with glioblastoma multiforme (GBM - WHO grade IV) seldom recover. This is due to the infiltrative nature of these tumours and the presence of cellular populations with ability to escape therapies and drive tumour recurrence and progression. In some cases, these resistant cells exhibit stem properties [glioma stem cells (GSC)]. This article aims at discussing relevant issues on GSC resistance to current therapies and outlines possible and promising avenues in regard to novel therapeutic strategies, such as pharmacological, immunological and viral interventions.

Entities: Disease Species

Mesh：

Substances：
Antineoplastic Agents

Year: 2010 PMID： 21185169 DOI： 10.1016/j.ejca.2010.11.017

Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162

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Cited

11 in total

1. Delayed formation of FancD2 foci in glioma stem cells treated with ionizing radiation.

Authors: Enrico Cappelli; Donatella Vecchio; Guido Frosina
Journal: J Cancer Res Clin Oncol Date: 2012-04-07 Impact factor: 4.553

2. Fusicoccin a, a phytotoxic carbotricyclic diterpene glucoside of fungal origin, reduces proliferation and invasion of glioblastoma cells by targeting multiple tyrosine kinases.

Authors: Marina Bury; Anna Andolfi; Bernard Rogister; Alessio Cimmino; Véronique Mégalizzi; Véronique Mathieu; Olivier Feron; Antonio Evidente; Robert Kiss
Journal: Transl Oncol Date: 2013-04-01 Impact factor: 4.243

3. Enhanced antitumor efficacy of low-dose Etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts.

Authors: Tooba A Cheema; Ryuichi Kanai; Geon Woo Kim; Hiroaki Wakimoto; Brent Passer; Samuel D Rabkin; Robert L Martuza
Journal: Clin Cancer Res Date: 2011-10-05 Impact factor: 12.531

4. Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.

Authors: Maria Zeniou; Marie Fève; Samir Mameri; Jihu Dong; Christophe Salomé; Wanyin Chen; Elias A El-Habr; Fanny Bousson; Mohamadou Sy; Julie Obszynski; Alexandre Boh; Pascal Villa; Suzana Assad Kahn; Bruno Didier; Dominique Bagnard; Marie-Pierre Junier; Hervé Chneiweiss; Jacques Haiech; Marcel Hibert; Marie-Claude Kilhoffer
Journal: PLoS One Date: 2015-08-13 Impact factor: 3.240

5. CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4.

Authors: Diana Aguilar-Morante; Jose A Morales-Garcia; Angel Santos; Ana Perez-Castillo
Journal: Oncotarget Date: 2015-02-28

Frontiers in targeting glioma stem cells.

1. Delayed formation of FancD2 foci in glioma stem cells treated with ionizing radiation.

2. Fusicoccin a, a phytotoxic carbotricyclic diterpene glucoside of fungal origin, reduces proliferation and invasion of glioblastoma cells by targeting multiple tyrosine kinases.

3. Enhanced antitumor efficacy of low-dose Etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts.

4. Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.

5. CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4.

6. Suppressing H19 Modulates Tumorigenicity and Stemness in U251 and U87MG Glioma Cells.

Review 7. Chemotherapeutic Drugs: DNA Damage and Repair in Glioblastoma.

8. TRAIL and paclitaxel synergize to kill U87 cells and U87-derived stem-like cells in vitro.

9. Cancer Stem Cells in Glioblastoma Multiforme.

Review 10. Long Non-Coding RNAs Dysregulation and Function in Glioblastoma Stem Cells.