PURPOSE: To assess health-related quality of life in patients with Kashin-Beck disease (KBD) in China. METHODS: A total of 684 participants from endemic areas of the Shaanxi province in China were recruited through a multistage stratified random sampling. Amongst those, 368 participants were diagnosed with KBD while the rest of 316 were non-KBD participants. Differences between KBD and non-KBD groups were analysed for the percentage of reporting any problems in each of EQ-5D five dimensions, EQ-5D index scores and visual analogue scale (VAS) scores. RESULTS: KBD patients have a higher percentage of reporting any problems in each of EQ-5D dimension than non-KBD participants and a general population in Beijing. The most affected dimension is pain/discomfort, followed by mobility, anxiety/depression, and usual activities, and self-care being the last. The mean EQ-5D index and VAS scores for KBD patients are significantly lower than those of non-KBD participants. CONCLUSION: This study is the first attempt to measure the health-related quality of life in KBD patients. The results of the study show that KBD has a severe impact on patients' health-related quality of life as measured by EQ-5D. It particularly causes great problems in the dimensions of pain/discomfort, mobility and anxiety/depression.
PURPOSE: To assess health-related quality of life in patients with Kashin-Beck disease (KBD) in China. METHODS: A total of 684 participants from endemic areas of the Shaanxi province in China were recruited through a multistage stratified random sampling. Amongst those, 368 participants were diagnosed with KBD while the rest of 316 were non-KBD participants. Differences between KBD and non-KBD groups were analysed for the percentage of reporting any problems in each of EQ-5D five dimensions, EQ-5D index scores and visual analogue scale (VAS) scores. RESULTS: KBD patients have a higher percentage of reporting any problems in each of EQ-5D dimension than non-KBD participants and a general population in Beijing. The most affected dimension is pain/discomfort, followed by mobility, anxiety/depression, and usual activities, and self-care being the last. The mean EQ-5D index and VAS scores for KBD patients are significantly lower than those of non-KBD participants. CONCLUSION: This study is the first attempt to measure the health-related quality of life in KBD patients. The results of the study show that KBD has a severe impact on patients' health-related quality of life as measured by EQ-5D. It particularly causes great problems in the dimensions of pain/discomfort, mobility and anxiety/depression.
Authors: M A Sprangers; E B de Regt; F Andries; H M van Agt; R V Bijl; J B de Boer; M Foets; N Hoeymans; A E Jacobs; G I Kempen; H S Miedema; M A Tijhuis; H C de Haes Journal: J Clin Epidemiol Date: 2000-09 Impact factor: 6.437
Authors: R Moreno-Reyes; C Suetens; F Mathieu; F Begaux; D Zhu; M T Rivera; M Boelaert; J Nève; N Perlmutter; J Vanderpas Journal: N Engl J Med Date: 1998-10-15 Impact factor: 91.245