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Literature DB >> 21183680

Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.

Cong Peng¹, Yong-Yeon Cho, Feng Zhu, Jishuai Zhang, Weihong Wen, Yanming Xu, Ke Yao, Wei-Ya Ma, Ann M Bode, Zigang Dong.

Abstract

The ribosomal S6 kinase 2 (RSK2) is a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins and plays a critical role in proliferation, cell cycle, and cell transformation. Here, we report that RSK2 phosphorylates caspase-8, and Thr-263 was identified as a novel caspase-8 phosphorylation site. In addition, we showed that EGF induces caspase-8 ubiquitination and degradation through the proteasome pathway, and phosphorylation of Thr-263 is associated with caspase-8 stability. Finally, RSK2 blocks Fas-induced apoptosis through its phosphorylation of caspase-8. These data provide a direct link between RSK2 and caspase-8 and identify a novel molecular mechanism for caspase-8 modulation by RSK2.

Entities: Chemical Gene

Mesh：

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Year: 2010 PMID： 21183680 PMCID： PMC3044950 DOI： 10.1074/jbc.M110.172338

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

27 in total

1. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

Authors: H k Huang; C A Joazeiro; E Bonfoco; S Kamada; J D Leverson; T Hunter
Journal: J Biol Chem Date: 2000-09-01 Impact factor: 5.157

Review 2. Mechanisms of caspase activation.

Authors: Kelly M Boatright; Guy S Salvesen
Journal: Curr Opin Cell Biol Date: 2003-12 Impact factor: 8.382

Review 3. Phosphorylation and acetylation of histone H3 at inducible genes: two controversies revisited.

Authors: Louis C Mahadevan; Alison L Clayton; Catherine A Hazzalin; Stuart Thomson
Journal: Novartis Found Symp Date: 2004

4. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.

Authors: Xiangli Yang; Koichi Matsuda; Peter Bialek; Sylvie Jacquot; Howard C Masuoka; Thorsten Schinke; Lingzhen Li; Stefano Brancorsini; Paolo Sassone-Corsi; Tim M Townes; Andre Hanauer; Gerard Karsenty
Journal: Cell Date: 2004-04-30 Impact factor: 41.582

5. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.

Authors: Y Suzuki; Y Nakabayashi; R Takahashi
Journal: Proc Natl Acad Sci U S A Date: 2001-07-10 Impact factor: 11.205

6. RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway.

Authors: Cong Peng; Yong-Yeon Cho; Feng Zhu; Yan-Ming Xu; Weihong Wen; Wei-Ya Ma; Ann M Bode; Zigang Dong
Journal: FASEB J Date: 2010-04-12 Impact factor: 5.191

7. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

Authors: E A Slee; C Adrain; S J Martin
Journal: J Biol Chem Date: 2000-10-31 Impact factor: 5.157

8. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.

Authors: A Bonni; A Brunet; A E West; S R Datta; M A Takasu; M E Greenberg
Journal: Science Date: 1999-11-12 Impact factor: 47.728

9. RSK2 activity is regulated by its interaction with PEA-15.

Authors: Hema Vaidyanathan; Joe W Ramos
Journal: J Biol Chem Date: 2003-06-09 Impact factor: 5.157

10. Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.

Authors: E Robert McDonald; Wafik S El-Deiry
Journal: Proc Natl Acad Sci U S A Date: 2004-04-06 Impact factor: 11.205

20 in total

Review 1. Cellular mechanisms controlling caspase activation and function.

Authors: Amanda B Parrish; Christopher D Freel; Sally Kornbluth
Journal: Cold Spring Harb Perspect Biol Date: 2013-06-01 Impact factor: 10.005

2. Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway.

Authors: Cong Peng; Feng Zhu; Weihong Wen; Ke Yao; Shengqing Li; Tatyana Zykova; Kangdong Liu; Xiang Li; Wei-Ya Ma; Ann M Bode; Zigang Dong
Journal: J Biol Chem Date: 2012-06-08 Impact factor: 5.157

Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.

1. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

Review 2. Mechanisms of caspase activation.

Review 3. Phosphorylation and acetylation of histone H3 at inducible genes: two controversies revisited.

4. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.

5. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.

6. RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway.

7. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

8. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.

9. RSK2 activity is regulated by its interaction with PEA-15.

10. Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.

Review 1. Cellular mechanisms controlling caspase activation and function.

2. Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway.

3. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis.

4. Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells.

5. Proteasomal regulation of caspase-8 in cancer cell apoptosis.

Review 6. Caspase control: protagonists of cancer cell apoptosis.

7. RSK2 as a key regulator in human skin cancer.

8. pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner.

9. DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells.

10. Modifications to a common phosphorylation network provide individualized control in caspases.