OBJECTIVES: The purpose of this study is to evaluate the feasibility of contrast-enhanced ultrasonography (CE-US) to differentiate between benign and malignant intraductal papillary mucinous neoplasms (IPMN). PATIENTS AND METHODS: Contrast-enhanced ultrasonography with a contrast agent was performed on 22 consecutive patients with IPMN suspected of being malignant. This revealed 10 carcinomas, 1 borderline lesion and 11 adenomas. All patients underwent surgery, and the histological diagnosis was confirmed by examination of resected specimens. CE-US was performed using a contrast agent. The detection rates of mural nodules were compared between CE-US and contrast-enhanced computed tomography (CE-CT), and the imaging of mural nodules depicted under CE-US was analyzed. RESULTS: Seventeen of 22 resected specimens (77.3%) had mural nodules. There was no significant difference in the detection rate between CE-US (n=15; 88.2%) and CE-CT (n=12; 70.6%). In 12 (80.0%) of these patients, CE-US revealed small vessels in the mural nodule. The spotty or linear-shaped pattern was detected in 4 patients and the branch-shaped pattern in 8. The branch-shaped pattern lesion was associated with carcinoma. These mural nodules were 10mm or more in height. In the perfusion image phase, cystic walls and mural nodules were also enhanced in all cases. CONCLUSION: The vessel shapes of the mural nodules depicted under CE-US were associated with size and pathological findings. These results suggested that CE-US with a contrast agent is a powerful modality with which to evaluate the malignant potential of IPMN.
OBJECTIVES: The purpose of this study is to evaluate the feasibility of contrast-enhanced ultrasonography (CE-US) to differentiate between benign and malignant intraductal papillary mucinous neoplasms (IPMN). PATIENTS AND METHODS: Contrast-enhanced ultrasonography with a contrast agent was performed on 22 consecutive patients with IPMN suspected of being malignant. This revealed 10 carcinomas, 1 borderline lesion and 11 adenomas. All patients underwent surgery, and the histological diagnosis was confirmed by examination of resected specimens. CE-US was performed using a contrast agent. The detection rates of mural nodules were compared between CE-US and contrast-enhanced computed tomography (CE-CT), and the imaging of mural nodules depicted under CE-US was analyzed. RESULTS: Seventeen of 22 resected specimens (77.3%) had mural nodules. There was no significant difference in the detection rate between CE-US (n=15; 88.2%) and CE-CT (n=12; 70.6%). In 12 (80.0%) of these patients, CE-US revealed small vessels in the mural nodule. The spotty or linear-shaped pattern was detected in 4 patients and the branch-shaped pattern in 8. The branch-shaped pattern lesion was associated with carcinoma. These mural nodules were 10mm or more in height. In the perfusion image phase, cystic walls and mural nodules were also enhanced in all cases. CONCLUSION: The vessel shapes of the mural nodules depicted under CE-US were associated with size and pathological findings. These results suggested that CE-US with a contrast agent is a powerful modality with which to evaluate the malignant potential of IPMN.
Authors: Asma Sultana; Richard Jackson; Gilbert Tim; Emma Bostock; Eftychia E Psarelli; Trevor F Cox; Robert Sutton; Paula Ghaneh; Michael G T Raraty; John P Neoptolemos; Christopher M Halloran Journal: Clin Transl Gastroenterol Date: 2015-12-10 Impact factor: 4.488
Authors: Nan Ge; William R Brugge; Payal Saxena; Anand Sahai; Douglas G Adler; Marc Giovannini; Nonthalee Pausawasdi; Erwin Santo; Girish Mishra; William Tam; Mitsuhiro Kida; Jose G de la Mora-Levy; Malay Sharma; Muhammad Umar; Akio Katanuma; Linda Lee; Pramod Kumar Garg; Mohamad Ali Eloubeidi; Ho Khek Yu; Isaac Raijman; Brenda Lucia Arturo Arias; Manoop Bhutani; Silvia Carrara; Praveer Rai; Shuntaro Mukai; Laurent Palazzo; Christoph F Dietrich; Nam Q Nguyen; Mohamed El-Nady; Jan Werner Poley; Simone Guaraldi; Evangelos Kalaitzakis; Luis Carlos Sabbagh; Jose Lariño-Noia; Frank G Gress; Yuk-Tong Lee; Surinder S Rana; Pietro Fusaroli; Michael Hocke; Vinay Dhir; Sundeep Lakhtakia; Thawee Ratanachu-Ek; A S Chalapathi Rao; Peter Vilmann; Hussein Hassan Okasha; Atsushi Irisawa; Ryan Ponnudurai; Ang Tiing Leong; Everson Artifon; Julio Iglesias-Garcia; Adrian Saftoiu; Alberto Larghi; Carlos Robles-Medranda; Siyu Sun Journal: Endosc Ultrasound Date: 2019 Nov-Dec Impact factor: 5.628