Literature DB >> 21183217

The art of identification of extravillous trophoblast.

G Moser1, K Orendi, M Gauster, M Siwetz, C Helige, B Huppertz.   

Abstract

Immunohistochemical staining with specific markers for the respective cell type facilitates tracking and identification of cells such as extravillous trophoblast in the uterine wall. Cytokeratin has been recommended as a marker for all kinds of trophoblasts and is commonly used as a marker to identify interstitial as well as endovascular trophoblast. With immunohistochemical double staining of specimens of first trimester placental bed we show that staining with anti-cytokeratin alone is not sufficient to track all routes of trophoblast invasion. Endovascular trophoblasts can be easily mixed up with endoglandular trophoblasts. Thus, additional application of specific markers for extravillous trophoblast such as anti-HLA-G is strongly recommended, ideally in combination with other markers in immunohistochemical or immunofluorescence double staining.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 21183217     DOI： 10.1016/j.placenta.2010.11.008

Source DB:  PubMed          Journal:  Placenta        ISSN： 0143-4004            Impact factor:   3.481


  13 in total

1.  Relaxin, its receptor (RXFP1), and insulin-like peptide 4 expression through gestation and in placenta accreta.

Authors:  William Goh; Sandra Y Yamamoto; Karen S Thompson; Gillian D Bryant-Greenwood
Journal:  Reprod Sci       Date:  2013-01-09       Impact factor: 3.060

Review 2.  Implantation and extravillous trophoblast invasion: From rare archival specimens to modern biobanking.

Authors:  Gerit Moser; Berthold Huppertz
Journal:  Placenta       Date:  2017-02-08       Impact factor: 3.481

3.  Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins.

Authors:  Gerit Moser; Gregor Weiss; Monika Sundl; Martin Gauster; Monika Siwetz; Ingrid Lang-Olip; Berthold Huppertz
Journal:  Histochem Cell Biol       Date:  2016-10-24       Impact factor: 4.304

4.  Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide.

Authors:  Jordan H Cater; Janet R Kumita; Rafaa Zeineddine Abdallah; Guomao Zhao; Ana Bernardo-Gancedo; Amanda Henry; Wendy Winata; Mengna Chi; Brin S F Grenyer; Michelle L Townsend; Marie Ranson; Catalin S Buhimschi; D Stephen Charnock-Jones; Christopher M Dobson; Mark R Wilson; Irina A Buhimschi; Amy R Wyatt
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-08       Impact factor: 11.205

5.  Evidence from the very beginning: endoglandular trophoblasts penetrate and replace uterine glands in situ and in vitro.

Authors:  G Moser; G Weiss; M Gauster; M Sundl; B Huppertz
Journal:  Hum Reprod       Date:  2015-10-22       Impact factor: 6.918

6.  Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A.

Authors:  Ursula Hiden; Christian P Eyth; Alejandro Majali-Martinez; Gernot Desoye; Carmen Tam-Amersdorfer; Berthold Huppertz; Nassim Ghaffari Tabrizi-Wizsy
Journal:  Histochem Cell Biol       Date:  2017-10-09       Impact factor: 4.304

Review 7.  Human trophoblast invasion: new and unexpected routes and functions.

Authors:  Gerit Moser; Karin Windsperger; Jürgen Pollheimer; Susana Chuva de Sousa Lopes; Berthold Huppertz
Journal:  Histochem Cell Biol       Date:  2018-07-26       Impact factor: 4.304

Review 8.  Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies.

Authors:  Gerit Moser; Sascha Drewlo; Berthold Huppertz; D Randall Armant
Journal:  Hum Reprod Update       Date:  2018-07-01       Impact factor: 15.610

Review 9.  Traditional and New Routes of Trophoblast Invasion and Their Implications for Pregnancy Diseases.

Authors:  Berthold Huppertz
Journal:  Int J Mol Sci       Date:  2019-12-31       Impact factor: 5.923

10.  Extracellularly Released Calreticulin Induced by Endoplasmic Reticulum Stress Impairs Syncytialization of Cytotrophoblast Model BeWo Cells.

Authors:  Naoyuki Iwahashi; Midori Ikezaki; Kazuchika Nishitsuji; Madoka Yamamoto; Ibu Matsuzaki; Naoki Kato; Naoyuki Takaoka; Mana Taniguchi; Shin-Ichi Murata; Kazuhiko Ino; Yoshito Ihara
Journal:  Cells       Date:  2021-05-24       Impact factor: 6.600
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