OBJECTIVE: The purpose of this study was to estimate the effect of bacterial vaginosis on midtrimester cervical length in women at increased risk for recurrent spontaneous preterm birth. STUDY DESIGN: We conducted a secondary analysis of prerandomization data from a multicenter trial of ultrasound-indicated cerclage. Women with previous spontaneous preterm birth at <34 weeks' gestation underwent initial cervical length assessment and vaginal fluid collection at 16-21 weeks 6 days gestation. Gram stains were scored with Nugent criteria. With serial scans, the shortest cervical length was observed. RESULTS: Records for 949 women had complete data. In unadjusted regression models, Nugent score (P = .003) and vaginal fluid pH (P = .008) were related inversely to cervical length. Women with bacterial vaginosis based on Nugent score ≥7 (P = .04) or pH ≥5 (P = .016) had significantly lower cervical length than unaffected women; however, all of these effects were null after covariate adjustment. CONCLUSION:Nugent score, pH level, and bacterial vaginosis are associated inversely with cervical length; however, these relationships become null after adjustment for relevant covariates.
RCT Entities:
OBJECTIVE: The purpose of this study was to estimate the effect of bacterial vaginosis on midtrimester cervical length in women at increased risk for recurrent spontaneous preterm birth. STUDY DESIGN: We conducted a secondary analysis of prerandomization data from a multicenter trial of ultrasound-indicated cerclage. Women with previous spontaneous preterm birth at <34 weeks' gestation underwent initial cervical length assessment and vaginal fluid collection at 16-21 weeks 6 days gestation. Gram stains were scored with Nugent criteria. With serial scans, the shortest cervical length was observed. RESULTS: Records for 949 women had complete data. In unadjusted regression models, Nugent score (P = .003) and vaginal fluid pH (P = .008) were related inversely to cervical length. Women with bacterial vaginosis based on Nugent score ≥7 (P = .04) or pH ≥5 (P = .016) had significantly lower cervical length than unaffected women; however, all of these effects were null after covariate adjustment. CONCLUSION: Nugent score, pH level, and bacterial vaginosis are associated inversely with cervical length; however, these relationships become null after adjustment for relevant covariates.
Authors: Dana Figueroa; Melissa S Mancuso; Jeff M Szychowski; Merri Maddox Paden; John Owen Journal: Am J Obstet Gynecol Date: 2010-11-05 Impact factor: 8.661
Authors: J Owen; N Yost; V Berghella; E Thom; M Swain; G A Dildy; M Miodovnik; O Langer; B Sibai; D McNellis Journal: JAMA Date: 2001-09-19 Impact factor: 56.272
Authors: P J Meis; R L Goldenberg; B Mercer; A Moawad; A Das; D McNellis; F Johnson; J D Iams; E Thom; W W Andrews Journal: Am J Obstet Gynecol Date: 1995-10 Impact factor: 8.661