| Literature DB >> 21183070 |
Christof Niehrs1, Sergio P Acebron.
Abstract
Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.Year: 2010 PMID： 21183070 DOI： 10.1016/j.cell.2010.12.003
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582