ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia paniculata Roxb. (Family-Combretaceae) is a wild tree commonly used in traditional ayurvedic medicine for the treatment of inflammation of parotid glands and in menstrual disorders. AIM OF THE STUDY: To explore the folk use of Terminalia paniculata on pharmacological grounds to evaluate the scientific basis of anti-inflammatory activity. MATERIALS AND METHODS: The anti-inflammatory activity of Terminalia paniculata was studied against carrageenan-induced hind paw edema, air pouch inflammation and complete Freund's adjuvant (CFA)-induced arthritis in rats. The aqueous extract of Terminalia paniculata bark (TPW) was administered at the concentrations of 100, 200 and 400mg/kg body weight. RESULTS: TPW showed significant (p<0.05) anti-inflammatory activity by reducing the edema volume in carrageenan-induced paw edema in rats. Further, TPW (400mg/kg) also reduced the carrageenan-induced leukocyte migration (50.92 ± 5.71%) and myeloperoxidase activity (49.31 ± 5.24%) in air pouch exudates. TPW (200mg/kg) exhibits anti-rheumatic and analgesic activities by improving the altered haematological milieu (ESR, CRP, RF, WBC, RBC and Hb) and also by inhibiting the flexion scores and radiographic changes in CFA-induced arthritis. This extract also had significant (p<0.05) effects on the occurrence of secondary lesions compared to CFA control. CONCLUSIONS: Terminalia paniculata bark may be a potential preventive or therapeutic candidate for the treatment of chronic inflammation and arthritis.
ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia paniculata Roxb. (Family-Combretaceae) is a wild tree commonly used in traditional ayurvedic medicine for the treatment of inflammation of parotid glands and in menstrual disorders. AIM OF THE STUDY: To explore the folk use of Terminalia paniculata on pharmacological grounds to evaluate the scientific basis of anti-inflammatory activity. MATERIALS AND METHODS: The anti-inflammatory activity of Terminalia paniculata was studied against carrageenan-induced hind paw edema, air pouch inflammation and complete Freund's adjuvant (CFA)-induced arthritis in rats. The aqueous extract of Terminalia paniculata bark (TPW) was administered at the concentrations of 100, 200 and 400mg/kg body weight. RESULTS:TPW showed significant (p<0.05) anti-inflammatory activity by reducing the edema volume in carrageenan-induced paw edema in rats. Further, TPW (400mg/kg) also reduced the carrageenan-induced leukocyte migration (50.92 ± 5.71%) and myeloperoxidase activity (49.31 ± 5.24%) in air pouch exudates. TPW (200mg/kg) exhibits anti-rheumatic and analgesic activities by improving the altered haematological milieu (ESR, CRP, RF, WBC, RBC and Hb) and also by inhibiting the flexion scores and radiographic changes in CFA-induced arthritis. This extract also had significant (p<0.05) effects on the occurrence of secondary lesions compared to CFA control. CONCLUSIONS:Terminalia paniculata bark may be a potential preventive or therapeutic candidate for the treatment of chronic inflammation and arthritis.
Authors: Antonia Amanda Cardoso de Almeida; Renan Oliveira Silva; Lucas Antonio Duarte Nicolau; Tarcísio Vieira de Brito; Damião Pergentino de Sousa; André Luiz Dos Reis Barbosa; Rivelilson Mendes de Freitas; Luciano da Silva Lopes; Jand-Venes Rolim Medeiros; Paulo Michel Pinheiro Ferreira Journal: Inflammation Date: 2017-04 Impact factor: 4.092
Authors: Maryam Farrukh; Uzma Saleem; Muhammad Qasim; Maria Manan; Muhammad Ajmal Shah Journal: Inflammopharmacology Date: 2022-02-26 Impact factor: 4.473
Authors: Francisco Valmor Macedo Cunha; Bruno de Sousa Gomes; Benedito de Sousa Neto; Alana Rodrigues Ferreira; Damião Pergentino de Sousa; Maria do Carmo de Carvalho e Martins; Francisco de Assis Oliveira Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2015-10-24 Impact factor: 3.000
Authors: Sania Aslam; Waqas Younis; Muhammad Nasir Hayat Malik; Shah Jahan; Ambreen Malik Uttra; Muhammad Usman Munir; Muhammad Roman Journal: Inflammopharmacology Date: 2022-03-23 Impact factor: 4.473