Literature DB >> 21181888

Stem Leydig cells: from fetal to aged animals.

Haolin Chen1, Erin Stanley, Shiying Jin, Barry R Zirkin.   

Abstract

Leydig cells are the testosterone-producing cells of the testis. The adult Leydig cell (ALC) population ultimately develops from undifferentiated mesenchymal-like stem cells present in the interstitial compartment of the neonatal testis. Distinct stages of ALC development have been identified and characterized. These include stem Leydig cells (SLCs), progenitor Leydig cells, immature Leydig cells, and ALCs. This review describes our current understanding of the SLCs in the fetal, prenatal, peripubertal, adult, and aged rat testis, as well as recent studies of the differentiation of steroidogenic cells from the stem cells of other organs. 2010 Wiley-Liss, Inc.

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Year:  2010        PMID： 21181888      PMCID： PMC4103425          DOI： 10.1002/bdrc.20192

Source DB:  PubMed          Journal:  Birth Defects Res C Embryo Today        ISSN： 1542-975X


  110 in total

Review 1.  Andropause: clinical implications of the decline in serum testosterone levels with aging in men.

Authors:  Alvin M Matsumoto
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2002-02       Impact factor: 6.053

2.  A developmental study of the Desert hedgehog-null mouse testis.

Authors:  F Pierucci-Alves; A M Clark; L D Russell
Journal:  Biol Reprod       Date:  2001-11       Impact factor: 4.285

3.  Steroidogenic and structural differentiation of new Leydig cell population following exposure of adult rats to ethane dimethanesulphonate.

Authors:  M Bakalska; I Koeva; N Atanassova; P Angelova; B Nikolov; M Davidoff
Journal:  Folia Biol (Praha)       Date:  2002       Impact factor: 0.906

Review 4.  One tissue, two fates: molecular genetic events that underlie testis versus ovary development.

Authors:  Jennifer Brennan; Blanche Capel
Journal:  Nat Rev Genet       Date:  2004-07       Impact factor: 53.242

5.  25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro.

Authors:  Jau-Jiin Chen; Yevgeniya Lukyanenko; James C Hutson
Journal:  Biol Reprod       Date:  2002-05       Impact factor: 4.285

6.  The role of the c-kit receptor in the regenerative differentiation of rat Leydig cells.

Authors:  Junji Tsuchida; Kayoko Dohmae; Yukihiko Kitamura; Yoshitake Nishimune
Journal:  Int J Androl       Date:  2003-04

7.  Effects of ethane dimethane sulfonate on the functional structure of the adult rat testis.

Authors:  S Ariyaratne; I Kim; N Mills; I Mason; C Mendis-Handagama
Journal:  Arch Androl       Date:  2003 Jul-Aug

8.  Evaluation of relative roles of LH and FSH in regulation of differentiation of Leydig cells using an ethane 1,2-dimethylsulfonate-treated adult rat model.

Authors:  V Sriraman; M R Sairam; A J Rao
Journal:  J Endocrinol       Date:  2003-01       Impact factor: 4.286

9.  Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad.

Authors:  Jennifer Brennan; Christopher Tilmann; Blanche Capel
Journal:  Genes Dev       Date:  2003-03-15       Impact factor: 11.361

10.  Müllerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation.

Authors:  Antonio Salva; Matthew P Hardy; Xiu-feng Wu; Chantal M Sottas; David T MacLaughlin; Patricia K Donahoe; Mary M Lee
Journal:  Biol Reprod       Date:  2003-10-29       Impact factor: 4.285
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  36 in total

1.  ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis.

Authors:  Jinjiang Fan; Xinlu Li; Leeyah Issop; Martine Culty; Vassilios Papadopoulos
Journal:  Mol Endocrinol       Date:  2016-05-11

2.  Directed mouse embryonic stem cells into leydig-like cells rescue testosterone-deficient male rats in vivo.

Authors:  Yan Yang; Zhijian Su; Wenting Xu; Jiao Luo; Rui Liang; Qi Xiang; Qihao Zhang; Ren-shan Ge; Yadong Huang
Journal:  Stem Cells Dev       Date:  2014-12-18       Impact factor: 3.272

3.  Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis.

Authors:  Qing Wen; Qiao-Song Zheng; Xi-Xia Li; Zhao-Yuan Hu; Fei Gao; C Yan Cheng; Yi-Xun Liu
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-10-21       Impact factor: 4.310

4.  Effects of spermatogenic cycle on Stem Leydig cell proliferation and differentiation.

Authors:  Xiaoju Guan; Fenfen Chen; Panpan Chen; Xingxing Zhao; Hongxia Mei; June Liu; Qingquan Lian; Barry R Zirkin; Haolin Chen
Journal:  Mol Cell Endocrinol       Date:  2018-11-23       Impact factor: 4.102

Review 5.  Defining vascular stem cells.

Authors:  Ching-Shwun Lin; Tom F Lue
Journal:  Stem Cells Dev       Date:  2013-01-18       Impact factor: 3.272

6.  Integrated Analysis of Multiple Biomarkers from Circulating Tumor Cells Enabled by Exclusion-Based Analyte Isolation.

Authors:  Jamie M Sperger; Lindsay N Strotman; Allison Welsh; Benjamin P Casavant; Zachery Chalmers; Sacha Horn; Erika Heninger; Stephanie M Thiede; Jacob Tokar; Benjamin K Gibbs; David J Guckenberger; Lakeesha Carmichael; Scott M Dehm; Philip J Stephens; David J Beebe; Scott M Berry; Joshua M Lang
Journal:  Clin Cancer Res       Date:  2016-07-11       Impact factor: 12.531

Review 7.  Essential roles of interstitial cells in testicular development and function.

Authors:  A Heinrich; T DeFalco
Journal:  Andrology       Date:  2019-09-30       Impact factor: 3.842

8.  Cellular microenvironment dictates androgen production by murine fetal Leydig cells in primary culture.

Authors:  Colleen M Carney; Jessica L Muszynski; Lindsay N Strotman; Samantha R Lewis; Rachel L O'Connell; David J Beebe; Ashleigh B Theberge; Joan S Jorgensen
Journal:  Biol Reprod       Date:  2014-08-20       Impact factor: 4.285

9.  Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes.

Authors:  Xiaoheng Li; Zhao Wang; Zhenming Jiang; Jingjing Guo; Yuxi Zhang; Chenhao Li; Jinyong Chung; Janet Folmer; June Liu; Qingquan Lian; Renshan Ge; Barry R Zirkin; Haolin Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-29       Impact factor: 11.205

10.  Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells.

Authors:  J Y Chung; H Chen; A Midzak; A L Burnett; V Papadopoulos; B R Zirkin
Journal:  Endocrinology       Date:  2013-03-22       Impact factor: 4.736
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