Literature DB >> 21181386

[Drooling following radiation. Botulinum toxin as a successful treatment modality].

A Steffen1, B Wollenberg, R Schönweiler, N Brüggemann, T Meyners.   

Abstract

Drooling is both a clinical sign for the diminished control of saliva and oral motor function and a heavy social burden for patients. We report a case in which drooling deteriorated after radiotherapy of the head and neck region as the primary treatment for hypopharyngeal cancer, although radiotherapy of the salivary glands is known to be an effective treatment option for drooling. In this particular case, injection of botulinum toxin in the parotid and submandibular glands significantly reduced drooling. The excellent response to botulinum toxin is of great clinical interest for similar RT non-responders.

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Year:  2011        PMID: 21181386     DOI: 10.1007/s00106-010-2232-5

Source DB:  PubMed          Journal:  HNO        ISSN: 0017-6192            Impact factor:   1.284


  12 in total

1.  External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis.

Authors:  P M Andersen; H Grönberg; L Franzen; U Funegård
Journal:  J Neurol Sci       Date:  2001-10-15       Impact factor: 3.181

Review 2.  A systematic review for evidence of efficacy of anticholinergic drugs to treat drooling.

Authors:  P H Jongerius; P van Tiel; J van Limbeek; F J M Gabreëls; J J Rotteveel
Journal:  Arch Dis Child       Date:  2003-10       Impact factor: 3.791

3.  Sparing the contralateral submandibular gland in oropharyngeal cancer patients: a planning study.

Authors:  Antonetta C Houweling; Tim Dijkema; Judith M Roesink; Chris H J Terhaard; Cornelis P J Raaijmakers
Journal:  Radiother Oncol       Date:  2008-05-22       Impact factor: 6.280

4.  [Quantitative and qualitative investigations of salivary gland function in dependence on irradiation dose and volume for reduction of xerostomia in patients with head-and-neck cancer].

Authors:  Thomas Kuhnt; Nicole Jirsak; Arndt Christian Müller; Tanja Pelz; Christian Gernhardt; Hans-Günter Schaller; Martin Janich; Reinhard Gerlach; Jürgen Dunst
Journal:  Strahlenther Onkol       Date:  2005-08       Impact factor: 3.621

Review 5.  Toxicity in head and neck cancer: a review of trends and issues.

Authors:  A Trotti
Journal:  Int J Radiat Oncol Biol Phys       Date:  2000-04-01       Impact factor: 7.038

6.  The role of radiation therapy in the management of sialorrhea.

Authors:  M Borg; F Hirst
Journal:  Int J Radiat Oncol Biol Phys       Date:  1998-07-15       Impact factor: 7.038

Review 7.  [Treatment of sialorrhea with botulinum toxin: an overview].

Authors:  J Hagenah; K G Kahl; S Steinlechner; R Lencer; C Klein
Journal:  Nervenarzt       Date:  2005-04       Impact factor: 1.214

8.  Dysphagia in multiple sclerosis.

Authors:  A De Pauw; E Dejaeger; B D'hooghe; H Carton
Journal:  Clin Neurol Neurosurg       Date:  2002-09       Impact factor: 1.876

9.  The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gland scintigraphy.

Authors:  Volker Rudat; Mark Münter; Dirk Rades; Knut A Grötz; Amira Bajrovic; Uwe Haberkorn; Winfried Brenner; Jürgen Debus
Journal:  Radiother Oncol       Date:  2008-08-15       Impact factor: 6.280

10.  [Radiotherapy : an option for refractory salivary fistulas].

Authors:  H Christiansen; H A Wolff; J Knauth; A Hille; H Vorwerk; C Engelke; R Rödel; R Laskawi
Journal:  HNO       Date:  2009-12       Impact factor: 1.284

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  3 in total

Review 1.  Hypersalivation: update of the German S2k guideline (AWMF) in short form.

Authors:  Armin Steffen; Wolfgang Jost; Tobias Bäumer; Dirk Beutner; Sabine Degenkolb-Weyers; Martin Groß; Maria Grosheva; Samer Hakim; Kai G Kahl; Rainer Laskawi; Rebekka Lencer; Jan Löhler; Thekla Meyners; Saskia Rohrbach-Volland; Rainer Schönweiler; Sara-Christina Schröder; Sebastian Schröder; Heidrun Schröter-Morasch; Maria Schuster; Susanne Steinlechner; Roland Urban; Orlando Guntinas-Lichius
Journal:  J Neural Transm (Vienna)       Date:  2019-04-10       Impact factor: 3.575

Review 2.  Therapy of Sialorrhea with Botulinum Neurotoxin.

Authors:  Wolfgang H Jost; Tobias Bäumer; Rainer Laskawi; Jaroslaw Slawek; Björn Spittau; Armin Steffen; Martin Winterholler; Ganesh Bavikatte
Journal:  Neurol Ther       Date:  2019-09-21

Review 3.  Botulinum Neurotoxins and Cancer-A Review of the Literature.

Authors:  Shivam Om Mittal; Bahman Jabbari
Journal:  Toxins (Basel)       Date:  2020-01-05       Impact factor: 4.546

  3 in total

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