INTRODUCTION: Human T cell lymphotropic virus type 1 (HTLV-I) myelopathy (HAM/TSP) is a progressive disabling disorder. This work aimed to analyze clinical features and epidemiology in a sample of HAM/TSP. METHODS: All HTLV-1 infected patients with diagnostic criteria for HAM/TSP, consecutively admitted to the Sarah Hospital from 1998 to 2007, were included in the study. RESULTS: 206 patients (67% females; mean age: 53.8 years-old) were diagnosed with HAM/TSP. The mean time of evolution was 9.0 years. The most common neurological symptoms were chronic progressive spastic paraparesis, spasticity, pain, neurogenic bladder and neurogenic bowel. The neurological findings were hyperreflexia, Babinsky, Hoffman and peripheral neuropathy. Pain, spasticity and spinal cord atrophy, observed in MRI, were associated with time of disease (p<0.05). CONCLUSIONS: HAM/TSP is a very disabling disorder, in which pain is reported early, while spasticity and thoracic spinal cord atrophy appear in a later phase of the disease. Cases of HAM/TSP exist with a probable vertical viral transmission.
INTRODUCTION:Human T cell lymphotropic virus type 1 (HTLV-I) myelopathy (HAM/TSP) is a progressive disabling disorder. This work aimed to analyze clinical features and epidemiology in a sample of HAM/TSP. METHODS: All HTLV-1 infectedpatients with diagnostic criteria for HAM/TSP, consecutively admitted to the Sarah Hospital from 1998 to 2007, were included in the study. RESULTS: 206 patients (67% females; mean age: 53.8 years-old) were diagnosed with HAM/TSP. The mean time of evolution was 9.0 years. The most common neurological symptoms were chronic progressive spastic paraparesis, spasticity, pain, neurogenic bladder and neurogenic bowel. The neurological findings were hyperreflexia, Babinsky, Hoffman and peripheral neuropathy. Pain, spasticity and spinal cord atrophy, observed in MRI, were associated with time of disease (p<0.05). CONCLUSIONS:HAM/TSP is a very disabling disorder, in which pain is reported early, while spasticity and thoracic spinal cord atrophy appear in a later phase of the disease. Cases of HAM/TSP exist with a probable vertical viral transmission.
Authors: Erika Pedreira da Fonseca; Katia Nunes Sá; Rebeca Freitas Reis Nunes; Camille Rosa de Jesus Souza; Mayra Castro de Matos Sousa; Elen Beatriz Pinto Journal: Rev Soc Bras Med Trop Date: 2021-01-29 Impact factor: 1.581
Authors: José Abraão Carneiro Neto; Cássius José Vitor de Oliveira; Sheila Nunes Ferraz; Mariele Guerra; Lívia Alves Oliveira; Lúcia Passos; Edgar M Carvalho; Paulo Novis Rocha Journal: PLoS Negl Trop Dis Date: 2022-01-14
Authors: Luiz C F Romanelli; Débora M Miranda; Anna B F Carneiro-Proietti; Marcelo Mamede; Herika M M Vasconcelos; Marina L Martins; Anísia S D Ferreira; Daniela V F Rosa; Jonas J Paula; Marco A Romano-Silva; Rodrigo Nicolato Journal: PLoS Negl Trop Dis Date: 2018-08-27