A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented.
A facile two-step method for the construction of fused pyrrole ring leading to n class="Chemical">5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented.
Authors: Robin Heckershoff; Steffen Maier; Thomas Wurm; Philipp Biegger; Kerstin Brödner; Petra Krämer; Marvin T Hoffmann; Lukas Eberle; Jana Stein; Frank Rominger; Matthias Rudolph; Jan Freudenberg; Andreas Dreuw; A Stephen K Hashmi; Uwe H F Bunz Journal: Chemistry Date: 2022-02-02 Impact factor: 5.020