| Literature DB >> 21180391 |
D Faccone1, L Guerriero, E Méndez, L Errecalde, H Cano, N Yoyas, A Togneri, V Romanowski, M Galas, Red Whonet, A Corso.
Abstract
Fluoroquinolone resistance is a growing problem that has only recently emerged in S. agalactiae. Between 2005-2007, WHONET--Argentina network evaluated levofloxacin susceptibility in 1128 clinical S. agalactiae isolates, 10 (0.9%) of which proved to be resistant. Nine of them had come from 5 hospitals (in Buenos Aires City and 4 Argentinean provinces) and recovered from urine (n=7) and vaginal screening cultures (n=2). Three strains were also resistant to macrolides, lincosamides and B streptogramins due to the ermA gene. All nine fluoroquinolone-resistant isolates bore the same two mutations, Ser79Phe in ParC and Ser81Leu in GyrA proteins. Genetic relationships were analyzed by Apal-PFGE and two clones were determined, A (n=6) and B (n=3). To our knowledge, these are the first fluoroquinolone-resistant S. agalactiae isolates detected in Latin America.Entities:
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Year: 2010 PMID： 21180391
Source DB: PubMed Journal: Rev Argent Microbiol ISSN： 0325-7541 Impact factor: 1.852