BACKGROUND: Brain natriureticpeptide (BNP) levels are elevated in patients with rheumatic mitral stenosis (MS) and decrease after a successful percutaneous transvenous mitral commissurotomy (PTMC). METHODS: In 37 consecutive patients of symptomatic MS (mean age 30 +/- 8.6 years) NTpro BNP levels were determined pre and 24-hours post PTMC. We seek to determine whether NT-pro-BNP levels be used as a marker of success of PTMC. RESULTS: PTMC was successful orpartial successful in 33 (89 %) cases. The mean NT-pro- BNP levels decreasedfrom 771 +/- 456 pg/ml to 700 +/- 595 pg/ml (p < 0.05) following PTMC. The mean NT-pro-BNP levels decreased by 20.6% in patients with a successful PTMC and decreased by 10.8% in patients with a partially successful PTMC, while the levels increased by 33.4% in patients with an unsuccessful procedure. Patients with associated aortic regurgitation failed to show a decline in NT-pro-BNP levels despite a successful procedure. CONCLUSION: NT-pro-BNP levels fall significantly after a successful PTMC, and a significant decrease in levels is a good marker of success of PTMC. It may not decrease in patients with associated aortic regurgitation despite a successfiul PTMC.
BACKGROUND: Brain natriureticpeptide (BNP) levels are elevated in patients with rheumatic mitral stenosis (MS) and decrease after a successful percutaneous transvenous mitral commissurotomy (PTMC). METHODS: In 37 consecutive patients of symptomatic MS (mean age 30 +/- 8.6 years) NTpro BNP levels were determined pre and 24-hours post PTMC. We seek to determine whether NT-pro-BNP levels be used as a marker of success of PTMC. RESULTS:PTMC was successful orpartial successful in 33 (89 %) cases. The mean NT-pro- BNP levels decreasedfrom 771 +/- 456 pg/ml to 700 +/- 595 pg/ml (p < 0.05) following PTMC. The mean NT-pro-BNP levels decreased by 20.6% in patients with a successful PTMC and decreased by 10.8% in patients with a partially successful PTMC, while the levels increased by 33.4% in patients with an unsuccessful procedure. Patients with associated aortic regurgitation failed to show a decline in NT-pro-BNP levels despite a successful procedure. CONCLUSION: NT-pro-BNP levels fall significantly after a successful PTMC, and a significant decrease in levels is a good marker of success of PTMC. It may not decrease in patients with associated aortic regurgitation despite a successfiul PTMC.
Authors: Santanu Guha; S Harikrishnan; Saumitra Ray; Rishi Sethi; S Ramakrishnan; Suvro Banerjee; V K Bahl; K C Goswami; Amal Kumar Banerjee; S Shanmugasundaram; P G Kerkar; Sandeep Seth; Rakesh Yadav; Aditya Kapoor; Ajaykumar U Mahajan; P P Mohanan; Sundeep Mishra; P K Deb; C Narasimhan; A K Pancholia; Ajay Sinha; Akshyaya Pradhan; R Alagesan; Ambuj Roy; Amit Vora; Anita Saxena; Arup Dasbiswas; B C Srinivas; B P Chattopadhyay; B P Singh; J Balachandar; K R Balakrishnan; Brian Pinto; C N Manjunath; Charan P Lanjewar; Dharmendra Jain; Dipak Sarma; G Justin Paul; Geevar A Zachariah; H K Chopra; I B Vijayalakshmi; J A Tharakan; J J Dalal; J P S Sawhney; Jayanta Saha; Johann Christopher; K K Talwar; K Sarat Chandra; K Venugopal; Kajal Ganguly; M S Hiremath; Milind Hot; Mrinal Kanti Das; Neil Bardolui; Niteen V Deshpande; O P Yadava; Prashant Bhardwaj; Pravesh Vishwakarma; Rajeeve Kumar Rajput; Rakesh Gupta; S Somasundaram; S N Routray; S S Iyengar; G Sanjay; Satyendra Tewari; Sengottuvelu G; Soumitra Kumar; Soura Mookerjee; Tiny Nair; Trinath Mishra; U C Samal; U Kaul; V K Chopra; V S Narain; Vimal Raj; Yash Lokhandwala Journal: Indian Heart J Date: 2018-06-08