OBJECTIVE: to map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. METHODS: genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. RESULTS: 1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area.
OBJECTIVE: to map a mousedeafness gene, identify the underlying mutation and develop a mouse model for humandeafness. METHODS: genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. RESULTS: 1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area.
Authors: P Kantheti; X Qiao; M E Diaz; A A Peden; G E Meyer; S L Carskadon; D Kapfhamer; D Sufalko; M S Robinson; J L Noebels; M Burmeister Journal: Neuron Date: 1998-07 Impact factor: 17.173
Authors: D Weil; S Blanchard; J Kaplan; P Guilford; F Gibson; J Walsh; P Mburu; A Varela; J Levilliers; M D Weston Journal: Nature Date: 1995-03-02 Impact factor: 49.962
Authors: F Gibson; J Walsh; P Mburu; A Varela; K A Brown; M Antonio; K W Beisel; K P Steel; S D Brown Journal: Nature Date: 1995-03-02 Impact factor: 49.962
Authors: Erwin Petek; Christian Windpassinger; Monika Mach; Ludwig Rauter; Stephen W Scherer; Klaus Wagner; Peter M Kroisel Journal: Am J Med Genet A Date: 2003-03-01 Impact factor: 2.802
Authors: Qing Yin Zheng; Christine R Rozanas; Isolde Thalmann; Mark R Chance; Kumar N Alagramam Journal: Brain Res Date: 2006-04-05 Impact factor: 3.252