BACKGROUND: Vitamin D deficiency is common worldwide. No homogenous reference values have yet been established and no studies of values have been conducted in Spain involving a large number of participants. OBJECTIVE: To study the population concentrations of vitamin D in a representative sample of the Spanish population. SUBJECTS/ METHODS: The study involved two cohorts from Spain, the Asturias study and the Pizarra study, which are two prospective, population-based studies involving 2260 participants. In 1262 subjects (age: 20-83 years) we studied 25-hydroxyvitamin D, intact parathyroid hormone (iPTH), calcium, phosphorus and creatinine. RESULTS: The median population values of 25-hydroxyvitamin D and iPTH were 22.46 ng/ml and 42.29 pg/ml, respectively. The values of 25-hydroxyvitamin D were significantly higher in summer and correlated with age (β = -0.05 ± 0.01, P < 0.0001), creatinine (β = 6.42 ± 1.17, P < 0.0001) and iPTH (-0.07 ± 0.01, P < 0.0001), but not with calcium, phosphorus or sex. The increase in iPTH with age was seen whatever the values of 25-hydroxyvitamin D, and was greater in the older persons. The concentration of iPTH rose continuously with effect from 25-hydroxyvitamin D values below ≈30 ng/ml. Values above ≈35 ng/ml were associated with a significantly lower concentration of iPTH. CONCLUSIONS: One-third (33.9%) of the Spanish population may be at risk for Vitamin D deficiency. The 25-hydroxyvitamin D values above 30 ng/ml can safely discard 'hyper PTH'. The increase in iPTH concentration is greater in older persons for similar values of 25-hydroxyvitamin D.
BACKGROUND:Vitamin D deficiency is common worldwide. No homogenous reference values have yet been established and no studies of values have been conducted in Spain involving a large number of participants. OBJECTIVE: To study the population concentrations of vitamin D in a representative sample of the Spanish population. SUBJECTS/ METHODS: The study involved two cohorts from Spain, the Asturias study and the Pizarra study, which are two prospective, population-based studies involving 2260 participants. In 1262 subjects (age: 20-83 years) we studied 25-hydroxyvitamin D, intact parathyroid hormone (iPTH), calcium, phosphorus and creatinine. RESULTS: The median population values of 25-hydroxyvitamin D and iPTH were 22.46 ng/ml and 42.29 pg/ml, respectively. The values of 25-hydroxyvitamin D were significantly higher in summer and correlated with age (β = -0.05 ± 0.01, P < 0.0001), creatinine (β = 6.42 ± 1.17, P < 0.0001) and iPTH (-0.07 ± 0.01, P < 0.0001), but not with calcium, phosphorus or sex. The increase in iPTH with age was seen whatever the values of 25-hydroxyvitamin D, and was greater in the older persons. The concentration of iPTH rose continuously with effect from 25-hydroxyvitamin D values below ≈30 ng/ml. Values above ≈35 ng/ml were associated with a significantly lower concentration of iPTH. CONCLUSIONS: One-third (33.9%) of the Spanish population may be at risk for Vitamin D deficiency. The 25-hydroxyvitamin D values above 30 ng/ml can safely discard 'hyper PTH'. The increase in iPTH concentration is greater in older persons for similar values of 25-hydroxyvitamin D.
Authors: Claudie Berger; Linda S Greene-Finestone; Lisa Langsetmo; Nancy Kreiger; Lawrence Joseph; Christopher S Kovacs; J Brent Richards; Nick Hidiroglou; Kurtis Sarafin; K Shawn Davison; Jonathan D Adachi; Jacques Brown; David A Hanley; Jerilynn C Prior; David Goltzman Journal: J Bone Miner Res Date: 2012-06 Impact factor: 6.741
Authors: Ruth Blanco-Rojo; Ana M Pérez-Granados; Laura Toxqui; Pilar Zazo; Concepción de la Piedra; M Pilar Vaquero Journal: Eur J Nutr Date: 2012-05-23 Impact factor: 5.614
Authors: Laura Toxqui; Ana M Pérez-Granados; Ruth Blanco-Rojo; Ione Wright; Concepción de la Piedra; M Pilar Vaquero Journal: Eur J Nutr Date: 2013-06-16 Impact factor: 5.614
Authors: André F S Amaral; Marinela Méndez-Pertuz; Alberto Muñoz; Debra T Silverman; Yves Allory; Manolis Kogevinas; Josep Lloreta; Nathaniel Rothman; Alfredo Carrato; Manuel Rivas del Fresno; Francisco X Real; Núria Malats Journal: J Natl Cancer Inst Date: 2012-10-29 Impact factor: 13.506