AIM: Exercise effects in subjects with HIV/AIDS are not entirely understood. The study aimed to investigate the effects of a supervised exercise program on the physical fitness and immunological function of HIV-infected subjects. METHODS:Twenty-seven highly active antiretroviral therapy treated HIV-infected patients (age: 45±2 years; CD4-T: 21.3±2.2%) were assigned to a control (CG, n=8) or experimental (EG, n=19) group. The EG participated in a 12-week exercise program, consisting of aerobic training, strength, and flexibility exercises (3 times/wk; aerobic-30min: PWC 150; strength-50min: 3 sets of 12 reps of 5 exercises at 60-80% 12 RM; flexibility-10min: 2 sets of 30 s at maximal range of motion of 8 exercises). RESULTS: Prior to training there was no significant difference in any variable between the EG and the CG. Flexibility (23%, P<0.05), 12 repetition maximum in the leg press and seated bilateral row exercises (54% and 65% respectively, P<0.05) increased, while the heart rate at a given cycle ergometer workload declined (19% for slope and 12% for intercept, P<0.05) in the EG, but not in the CG. No significant differences were found for the relative and absolute CD4 T-cell counts between groups prior to or after training, but there was a slight enhancement trend in the EG (16%, P=0.19). CONCLUSION: Overall training can improve the muscle and aerobic fitness of HIV-infected patients with no negative effect on their immunological function.
RCT Entities:
AIM: Exercise effects in subjects with HIV/AIDS are not entirely understood. The study aimed to investigate the effects of a supervised exercise program on the physical fitness and immunological function of HIV-infected subjects. METHODS: Twenty-seven highly active antiretroviral therapy treated HIV-infectedpatients (age: 45±2 years; CD4-T: 21.3±2.2%) were assigned to a control (CG, n=8) or experimental (EG, n=19) group. The EG participated in a 12-week exercise program, consisting of aerobic training, strength, and flexibility exercises (3 times/wk; aerobic-30min: PWC 150; strength-50min: 3 sets of 12 reps of 5 exercises at 60-80% 12 RM; flexibility-10min: 2 sets of 30 s at maximal range of motion of 8 exercises). RESULTS: Prior to training there was no significant difference in any variable between the EG and the CG. Flexibility (23%, P<0.05), 12 repetition maximum in the leg press and seated bilateral row exercises (54% and 65% respectively, P<0.05) increased, while the heart rate at a given cycle ergometer workload declined (19% for slope and 12% for intercept, P<0.05) in the EG, but not in the CG. No significant differences were found for the relative and absolute CD4 T-cell counts between groups prior to or after training, but there was a slight enhancement trend in the EG (16%, P=0.19). CONCLUSION: Overall training can improve the muscle and aerobic fitness of HIV-infectedpatients with no negative effect on their immunological function.
Authors: Suhitha Veeravelli; Bijan Najafi; Ivan Marin; Fernando Blumenkron; Shannon Smith; Stephen A Klotz Journal: J Vis Exp Date: 2016-10-06 Impact factor: 1.355
Authors: Lorena da Silva Paes; Juliana Pereira Borges; Fernanda Monteiro Dos Santos; Taciana Pinto de Oliveira; Jaciara Gomes Dupin; Elizabeth Assumpção Harris; Paulo Farinatti Journal: Open AIDS J Date: 2015-10-20
Authors: Camilo Germán Alberto Pérez Chaparro; Philipp Zech; Felipe Schuch; Bernd Wolfarth; Michael Rapp; Andreas Heiβel Journal: PLoS One Date: 2018-09-04 Impact factor: 3.240