Pascale Schwab1, Kenneth Scalapino. 1. Portland Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon, USA. schwabp@ohsu.edu
Abstract
PURPOSE OF REVIEW: Patients frequently inquire about exercise as a means to improve bone strength and reduce osteoporotic fracture. Understanding the biologic mechanisms and the available clinical evidence supporting the role of exercise in bone health is the key to an educated discussion. RECENT FINDINGS: Exercise downregulates sclerostin expression by the osteocyte favoring osteoblastogenesis. These changes are enhanced by dynamic cyclical load with rest periods and may be promoted by low-amplitude high-frequency stimuli. In the prepubertal years, exercise results in periosteal gains, whereas exercise later in life maintains bone mass, reduces falls and probably associated fractures, and improves quality-of-life measures. SUMMARY: Future studies should examine the effect of exercise on bone strength and determine the minimum quantity and frequency and the exercise type most effective to reduce osteoporotic fractures.
PURPOSE OF REVIEW: Patients frequently inquire about exercise as a means to improve bone strength and reduce osteoporotic fracture. Understanding the biologic mechanisms and the available clinical evidence supporting the role of exercise in bone health is the key to an educated discussion. RECENT FINDINGS: Exercise downregulates sclerostin expression by the osteocyte favoring osteoblastogenesis. These changes are enhanced by dynamic cyclical load with rest periods and may be promoted by low-amplitude high-frequency stimuli. In the prepubertal years, exercise results in periosteal gains, whereas exercise later in life maintains bone mass, reduces falls and probably associated fractures, and improves quality-of-life measures. SUMMARY: Future studies should examine the effect of exercise on bone strength and determine the minimum quantity and frequency and the exercise type most effective to reduce osteoporotic fractures.
Authors: Joao Pedro Pinho; Arturo Forner-Cordero; Rosa Maria Rodrigues Pereira; Arnaldo Jose Hernandez; Egidio Lima Dorea; Bruno Mezencio; Liliam Takayama; Jackeline Couto Alvarenga; Julio Cerca Serrao; Alberto Carlos Amadio Journal: IEEE J Transl Eng Health Med Date: 2020-01-03 Impact factor: 3.316
Authors: Sandra L Amaral; Liane B Azevedo; Marilia A R Buzalaf; Mayara F Fabricio; Mileni S Fernandes; Ruth A Valentine; Anne Maguire; Fatemeh V Zohoori Journal: Sci Rep Date: 2018-02-16 Impact factor: 4.379