Literature DB >> 21178465

The relevance of heat shock regulation in fungal pathogens of humans.

Alistair J P Brown1, Michelle D Leach, Susan Nicholls.   

Abstract

Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.

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Year:  2010        PMID： 21178465      PMCID： PMC3073299          DOI： 10.4161/viru.1.4.12364

Source DB:  PubMed          Journal:  Virulence        ISSN： 2150-5594            Impact factor:   5.882


  33 in total

1.  Integrative model of the response of yeast to osmotic shock.

Authors:  Edda Klipp; Bodil Nordlander; Roland Krüger; Peter Gennemark; Stefan Hohmann
Journal:  Nat Biotechnol       Date:  2005-07-17       Impact factor: 54.908

2.  Hsp90 as a capacitor for morphological evolution.

Authors:  S L Rutherford; S Lindquist
Journal:  Nature       Date:  1998-11-26       Impact factor: 49.962

3.  A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis.

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Journal:  Infect Immun       Date:  1998-05       Impact factor: 3.441

4.  Autoantibody to heat-shock protein 90 can mediate protection against systemic candidosis.

Authors:  R C Matthews; J P Burnie; D Howat; T Rowland; F Walton
Journal:  Immunology       Date:  1991-09       Impact factor: 7.397

5.  Evidence for presence in the cell wall of Candida albicans of a protein related to the hsp70 family.

Authors:  J L López-Ribot; H M Alloush; B J Masten; W L Chaffin
Journal:  Infect Immun       Date:  1996-08       Impact factor: 3.441

6.  Structure and regulation of the HSP90 gene from the pathogenic fungus Candida albicans.

Authors:  R K Swoboda; G Bertram; S Budge; G W Gooday; N A Gow; A J Brown
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

7.  A Candida albicans chaperonin subunit (CaCct8p) as a suppressor of morphogenesis and Ras phenotypes in C. albicans and Saccharomyces cerevisiae.

Authors:  Felicitas Rademacher; Verena Kehren; Volker R Stoldt; Joachim F Ernst
Journal:  Microbiology (Reading)       Date:  1998-11       Impact factor: 2.777

8.  Isolation of immunodominant antigens from sera of patients with systemic candidiasis and characterization of serological response to Candida albicans.

Authors:  R C Matthews; J P Burnie; S Tabaqchali
Journal:  J Clin Microbiol       Date:  1987-02       Impact factor: 5.948

9.  Heat-inducible ATP-binding proteins of Candida albicans are recognized by sera of infected patients.

Authors:  R Swoboda; S Miyasaki; D Greenspan; J S Greenspan
Journal:  J Gen Microbiol       Date:  1993-12

10.  The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans.

Authors:  A M Alarco; M Raymond
Journal:  J Bacteriol       Date:  1999-02       Impact factor: 3.490
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  10 in total

Review 1.  Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.

Authors:  Jacob Verghese; Jennifer Abrams; Yanyu Wang; Kevin A Morano
Journal:  Microbiol Mol Biol Rev       Date:  2012-06       Impact factor: 11.056

2.  The heat-induced molecular disaggregase Hsp104 of Candida albicans plays a role in biofilm formation and pathogenicity in a worm infection model.

Authors:  Alessandro Fiori; Sona Kucharíková; Gilmer Govaert; Bruno P A Cammue; Karin Thevissen; Patrick Van Dijck
Journal:  Eukaryot Cell       Date:  2012-05-25

3.  Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans.

Authors:  Darpan Saraswat; Rohitashw Kumar; Tanaya Pande; Mira Edgerton; Paul J Cullen
Journal:  Mol Microbiol       Date:  2016-02-10       Impact factor: 3.501

Review 4.  Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis.

Authors:  Liliana Scorzoni; Ana C A de Paula E Silva; Caroline M Marcos; Patrícia A Assato; Wanessa C M A de Melo; Haroldo C de Oliveira; Caroline B Costa-Orlandi; Maria J S Mendes-Giannini; Ana M Fusco-Almeida
Journal:  Front Microbiol       Date:  2017-01-23       Impact factor: 5.640

5.  Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.

Authors:  Jinglin L Xie; Iryna Bohovych; Erin O Y Wong; Jean-Philippe Lambert; Anne-Claude Gingras; Oleh Khalimonchuk; Leah E Cowen; Michelle D Leach
Journal:  Microb Cell       Date:  2017-10-02

6.  Transient intracellular acidification regulates the core transcriptional heat shock response.

Authors:  Catherine G Triandafillou; Christopher D Katanski; Aaron R Dinner; D Allan Drummond
Journal:  Elife       Date:  2020-08-07       Impact factor: 8.713

7.  Heat Shock Proteins in Dermatophytes: Current Advances and Perspectives.

Authors:  Nilce M Martinez-Rossi; Tiago R Jacob; Pablo R Sanches; Nalu T A Peres; Elza A S Lang; Maíra P Martins; Antonio Rossi
Journal:  Curr Genomics       Date:  2016-04       Impact factor: 2.236

8.  Heat Shock Protein 90 (Hsp90) as a Molecular Target for the Development of Novel Drugs Against the Dermatophyte Trichophyton rubrum.

Authors:  Tiago R Jacob; Nalu T A Peres; Maíra P Martins; Elza A S Lang; Pablo R Sanches; Antonio Rossi; Nilce M Martinez-Rossi
Journal:  Front Microbiol       Date:  2015-11-10       Impact factor: 5.640

9.  Proteins Potentially Involved in Immune Evasion Strategies in Sporothrix brasiliensis Elucidated by Ultra-High-Resolution Mass Spectrometry.

Authors:  Luana Rossato; Leandro Ferreira Moreno; Azadeh Jamalian; Benjamin Stielow; Sandro Rogério de Almeida; Sybren de Hoog; Joanna Freeke
Journal:  mSphere       Date:  2018-06-13       Impact factor: 4.389

10.  A conserved fungal hub protein involved in adhesion and drug resistance in the human pathogen Candida albicans.

Authors:  Hélène Martin-Yken; Tina Bedekovic; Alexandra C Brand; Mathias L Richard; Sadri Znaidi; Christophe d'Enfert; Etienne Dague
Journal:  Cell Surf       Date:  2018-10-29
  10 in total

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