BACKGROUND: The association of human leukocyte antigen (HLA) genes and multiple sclerosis (MS) has been extensively investigated in Caucasians, but less so in Oriental races such as Chinese. OBJECTIVES: To review studies on association of HLA class II alleles with MS in the Chinese population. METHODS: An extensive search for published studies up to June 2010 was performed in the electronic databases. The meta-analysis facilities in the NCSS statistical package were utilized to analyze the findings in these studies. The odds ratios (ORs) of HLA-DR allele distributions in MS were analyzed against controls. RESULTS: Eleven case-control studies were identified: nine genotyping and two serotyping studies. Six genotyping studies were suitable for HLA-DRB1 allele meta-analysis, which showed that HLA-DRB1*15 was associated with risk of MS in the combined group (308 cases and 407 controls; OR 1.39) while the HLA-DRB1*09 and HLA-DRB1*0901 alleles were protective. When the equivalent serotypes in these six studies were combined with the results from the two serotyping studies (431 cases and 652 controls) for a meta-analysis of HLA-DR serotypes, HLA-DR2 was a risk factor (OR 1.63) and HLA-DR9 was strongly protective in the combined group (OR 0.64). CONCLUSIONS: Although limited data are available, our meta-analysis suggests that HLA-DR2/DRB1*15 are also associated with risk of MS in the Chinese population but less strongly so than in Western MS populations, whereas HLA-DR9 alleles appear to confer resistance in this population.
BACKGROUND: The association of human leukocyte antigen (HLA) genes and multiple sclerosis (MS) has been extensively investigated in Caucasians, but less so in Oriental races such as Chinese. OBJECTIVES: To review studies on association of HLA class II alleles with MS in the Chinese population. METHODS: An extensive search for published studies up to June 2010 was performed in the electronic databases. The meta-analysis facilities in the NCSS statistical package were utilized to analyze the findings in these studies. The odds ratios (ORs) of HLA-DR allele distributions in MS were analyzed against controls. RESULTS: Eleven case-control studies were identified: nine genotyping and two serotyping studies. Six genotyping studies were suitable for HLA-DRB1 allele meta-analysis, which showed that HLA-DRB1*15 was associated with risk of MS in the combined group (308 cases and 407 controls; OR 1.39) while the HLA-DRB1*09 and HLA-DRB1*0901 alleles were protective. When the equivalent serotypes in these six studies were combined with the results from the two serotyping studies (431 cases and 652 controls) for a meta-analysis of HLA-DR serotypes, HLA-DR2 was a risk factor (OR 1.63) and HLA-DR9 was strongly protective in the combined group (OR 0.64). CONCLUSIONS: Although limited data are available, our meta-analysis suggests that HLA-DR2/DRB1*15 are also associated with risk of MS in the Chinese population but less strongly so than in Western MS populations, whereas HLA-DR9 alleles appear to confer resistance in this population.
Authors: Lisa E Creary; Kalyan C Mallempati; Sridevi Gangavarapu; Stacy J Caillier; Jorge R Oksenberg; Marcelo A Fernández-Viňa Journal: Mult Scler Date: 2018-04-23 Impact factor: 6.312
Authors: Noriko Isobe; Pierre-Antoine Gourraud; Hanne F Harbo; Stacy J Caillier; Adam Santaniello; Pouya Khankhanian; Martin Maiers; Stephen Spellman; Nezih Cereb; SooYoung Yang; Marcelo J Pando; Laura Piccio; Anne H Cross; Philip L De Jager; Bruce A C Cree; Stephen L Hauser; Jorge R Oksenberg Journal: Neurology Date: 2013-06-14 Impact factor: 9.910
Authors: A De Silvestri; C Capittini; G Mallucci; R Bergamaschi; C Rebuffi; A Pasi; M Martinetti; C Tinelli Journal: Dis Markers Date: 2019-11-06 Impact factor: 3.434