OBJECTIVES: To evaluate the effect of bakumondoto, Kampo medicine, on cough in patients with chronic obstructive pulmonary disease (COPD). DESIGN: A 16-week, randomized, open-labeled, cross-over design. SETTING:Outpatient clinics at one university hospital and two general hospitals in Japan from May 2007 to March 2009. PARTICIPANTS: Twenty-four elderly patients (14 men and 9 women aged over 65) with COPD. INTERVENTION: Treatment with or without bakumondoto for 8 weeks in a cross-over design. MEASUREMENTS: The primary outcome measurements were the frequency and intensity of cough assessed by a visual analogue scale (VAS) and a daily cough diary. Secondary outcome measurements were quality of life (QOL) assessed using St. George's Respiratory Questionnaire (SGRQ) and lung functions measured using spirometry. RESULTS: Treatment with bakumondoto significantly improved cough severity during the first treatment period (week 0 vs. week 8, p=0.004) and showed a trend to decrease during the second treatment period (week 8 vs. week 16, p=0.129) assessed by the VAS. Neither QOL nor lung function was affected by the treatment with bakumondoto. CONCLUSION: Bakumondoto may be effective in suppressing cough in elderly patients with COPD. To further confirm the efficacy, a larger and placebo-controlled study with objective cough assessment is necessary.
RCT Entities:
OBJECTIVES: To evaluate the effect of bakumondoto, Kampo medicine, on cough in patients with chronic obstructive pulmonary disease (COPD). DESIGN: A 16-week, randomized, open-labeled, cross-over design. SETTING:Outpatient clinics at one university hospital and two general hospitals in Japan from May 2007 to March 2009. PARTICIPANTS: Twenty-four elderly patients (14 men and 9 women aged over 65) with COPD. INTERVENTION: Treatment with or without bakumondoto for 8 weeks in a cross-over design. MEASUREMENTS: The primary outcome measurements were the frequency and intensity of cough assessed by a visual analogue scale (VAS) and a daily cough diary. Secondary outcome measurements were quality of life (QOL) assessed using St. George's Respiratory Questionnaire (SGRQ) and lung functions measured using spirometry. RESULTS: Treatment with bakumondoto significantly improved cough severity during the first treatment period (week 0 vs. week 8, p=0.004) and showed a trend to decrease during the second treatment period (week 8 vs. week 16, p=0.129) assessed by the VAS. Neither QOL nor lung function was affected by the treatment with bakumondoto. CONCLUSION: Bakumondoto may be effective in suppressing cough in elderly patients with COPD. To further confirm the efficacy, a larger and placebo-controlled study with objective cough assessment is necessary.
Authors: Hai Yong Chen; Chun Ho Ma; Ke-Jian Cao; James Chung-Man Ho; Eric Ziea; Vivian Taam Wong; Zhang-Jin Zhang Journal: Evid Based Complement Alternat Med Date: 2014-03-26 Impact factor: 2.629
Authors: Meaghan Coyle; Johannah Linda Shergis; Shaonan Liu; Lei Wu; Anthony Lin Zhang; Xinfeng Guo; Chuanjian Lu; Charlie Changli Xue Journal: Evid Based Complement Alternat Med Date: 2015-03-26 Impact factor: 2.629
Authors: Fernanda Paula R Santana; Nathalia M Pinheiro; Márcia Isabel B Mernak; Renato F Righetti; Mílton A Martins; João H G Lago; Fernanda D T Q Dos Santos Lopes; Iolanda F L C Tibério; Carla M Prado Journal: Mediators Inflamm Date: 2016-06-29 Impact factor: 4.711