Literature DB >> 21176778

Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance.

Sophie Turban1, Eric Hajduch.   

Abstract

The role of protein kinase C (PKCs) isoforms in the regulation of glucose metabolism by insulin is complex, partly due to the large PKC family consisting of three sub-groups: conventional, novel and atypical. Activation of some conventional and novel PKCs in response to increased levels of diacylglycerol (DAG) have been shown to counteract insulin signalling. However, roles of atypical PKCs (aPKCs) remain poorly understood. aPKCs act as molecular switches by promoting or suppressing signalling pathways, in response to insulin or ceramides respectively. Understanding how DAG- and ceramide-activated PKCs impair insulin signalling would help to develop treatments to fight insulin resistance.
Copyright © 2010 Federation of European Biochemical Societies. All rights reserved.

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Year:  2010        PMID： 21176778     DOI： 10.1016/j.febslet.2010.12.022

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  43 in total

1.  Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells.

Authors:  R Hage Hassan; I Hainault; J-T Vilquin; C Samama; F Lasnier; P Ferré; F Foufelle; E Hajduch
Journal:  Diabetologia       Date:  2011-10-18       Impact factor: 10.122

Review 2.  Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.

Authors:  Christian K Roberts; Andrea L Hevener; R James Barnard
Journal:  Compr Physiol       Date:  2013-01       Impact factor: 9.090

Review 3.  Insulin resistance in clinical and experimental alcoholic liver disease.

Authors:  Rotonya M Carr; Jason Correnti
Journal:  Ann N Y Acad Sci       Date:  2015-05-21       Impact factor: 5.691

Review 4.  Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise.

Authors:  Gregory D Cartee
Journal:  Am J Physiol Endocrinol Metab       Date:  2015-10-20       Impact factor: 4.310

5.  Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.

Authors:  Jianwen Wei; Mathieu Ferron; Christopher J Clarke; Yusuf A Hannun; Hongfeng Jiang; William S Blaner; Gerard Karsenty
Journal:  J Clin Invest       Date:  2014-03-18       Impact factor: 14.808

6.  Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance.

Authors:  Matthew Van Beek; Katherine I Oravecz-Wilson; Phillip C Delekta; Shufang Gu; Xiangquan Li; Xiaohong Jin; Ingrid J Apel; Katy S Konkle; Yongjia Feng; Daniel H Teitelbaum; Jürgen Ruland; Linda M McAllister-Lucas; Peter C Lucas
Journal:  Cell Rep       Date:  2012-05-31       Impact factor: 9.423

Review 7.  Insulin receptor signaling in normal and insulin-resistant states.

Authors:  Jérémie Boucher; André Kleinridders; C Ronald Kahn
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-01-01       Impact factor: 10.005

8.  Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE.

Authors:  Rima Hage Hassan; Ana Catarina Pacheco de Sousa; Rana Mahfouz; Isabelle Hainault; Agnieszka Blachnio-Zabielska; Olivier Bourron; Fabien Koskas; Jan Górski; Pascal Ferré; Fabienne Foufelle; Eric Hajduch
Journal:  J Biol Chem       Date:  2015-12-23       Impact factor: 5.157

Review 9.  Defect of insulin signal in peripheral tissues: Important role of ceramide.

Authors:  Rima Hage Hassan; Olivier Bourron; Eric Hajduch
Journal:  World J Diabetes       Date:  2014-06-15

Review 10.  Knockout mouse models of insulin signaling: Relevance past and future.

Authors:  Anne E Bunner; P Charukeshi Chandrasekera; Neal D Barnard
Journal:  World J Diabetes       Date:  2014-04-15
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