Literature DB >> 2117660

Interferon-gamma induced exacerbation of systemic lupus erythematosus.

K P Machold1, J S Smolen.   

Abstract

A patient with presumed rheumatoid arthritis based on clinical and serological evidence was subjected by her physician to interferon-gamma (IFN-gamma) therapy and developed a life threatening multiorgan flare of systemic lupus erythematosus (SLE). Pulse cyclophosphamide therapy in conjunction with plasmapheresis led to complete remission. Retrospective analysis of serum drawn before IFN-gamma was started revealed high DNA binding capacity. Thus, similar to observations in lupus-prone animals, IFN-gamma may have induced an exacerbation of preexisting SLE.

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Year:  1990        PMID： 2117660

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


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